The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic†
Achintya Bandyopadhyaya,Desikan R. Rajagopalan,Nigam P. Rath,Amy Herrold,Raghavan Rajagopalan,T. Celesete Napier,Clark E. Tedford,Parthasarathi Rajagopalan
A new pentacyclic compound, DDD-016 (10d) was designed and synthesized as a potential antipsychotic and screened for binding affinity in a broad panel of over 80 CNS and other receptors, monoamine transporters, and ion channels. The resulting receptor binding profile of DDD-016 is consistent with that of an improved atypical antipsychotic candidate.
