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A second generation MRI contrast agent for imaging zinc ionsin vivo†
Luis M. De León-Rodríguez,Angelo J. M. Lubag,Jorge A. López,Gabriel Andreu-de-Riquer,José C. Alvarado-Monzón,A. Dean Sherry
MedChemComm Pub Date : 03/07/2012 00:00:00 , DOI:10.1039/C2MD00301E
Abstract

A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.

Graphical abstract: A second generation MRI contrast agent for imaging zinc ions in vivo
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