A concise synthesis of the potent inflammatory mediator 5-oxo-ETE†,10.1039/C1MD00231G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A concise synthesis of the potent inflammatory mediator 5-oxo-ETE†

Rahul Tyagi,Bharat Shimpukade,Stefanie Blättermann,Evi Kostenis,Trond Ulven

MedChemComm Pub Date : 10/20/2011 00:00:00 , DOI:10.1039/C1MD00231G

Abstract

A concise and practical method for synthesis of the potent inflammatory mediator 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE, 1) from arachidonic acid in four steps and 70% overall yield is reported. Stability studies indicate that 1 can be safely handled without rigorous precautions.