Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors†
Xinyi Song,Yuanjun He,Marcel Koenig,Youseung Shin,Romain Noel,Weimin Chen,Yuan Yuan Ling,Daniel Feurstein,Li Lin,Claudia H. Ruiz,Michael D. Cameron,Derek R. Duckett,Theodore M. Kamenecka
Abstract
The design and synthesis of a potent series of c-jun N-terminal kinase (JNK2) inhibitors is described. The development and optimization of the 2,4-diaminopyrimidines series was carried out from an earlier in-house kinase inhibitor program. Through the optimization of the scaffold 2, several cell potent compounds with good in vivo profiles were discovered.
