Blockage of collagen binding to integrin α2β1: structure–activity relationship of protein–protein interaction inhibitors†,10.1039/C1MD00089F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Blockage of collagen binding to integrin α2β1: structure–activity relationship of protein–protein interaction inhibitors†

Liisa Nissinen,Auni Juhakoski,Marjo Pihlavisto,Anne Marjamäki

MedChemComm Pub Date : 06/22/2011 00:00:00 , DOI:10.1039/C1MD00089F

Abstract

The interaction between the α2β1 integrin and collagen plays a crucial role in the development of pathological conditions, such as thrombus formation and cancer cell metastasis. Accordingly, the α2β1 integrin is a promising target for the development of new drug molecules to treat these diseases. Here, we have designed, synthesized, and measured in vitro a set of novel drug-like compounds that block the protein–protein interactions between α2β1 integrin and collagen. The obtained structure–activity relationship reveals the key features that are required for successful inhibition of this integrin–collagen interaction.