Two homochiral compounds (H2-MPA)(CCl3COO)2 (1) and (H2-quinine)2(BiCl6)·Cl·H2O (2) [MPA = (R)-2-methylpiperazine] that exhibit good piezoelectric properties with a temperature-independent feature are obtained. Our novel findings on temperature-independent piezoelectric properties will provide a new impetus in this field of materials science