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Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface
C. Piccirillo,S. Perni,J. Gil-Thomas,P. Prokopovich,M. Wilson,J. Pratten,I. P. Parkin
Journal of Materials Chemistry Pub Date : 07/06/2009 00:00:00 , DOI:10.1039/B905495B
Abstract

Methylene Blue or Toluidine Blue O were covalently bound to an activated silicone polymer by means of an amide condensation reaction. UV-visible absorption spectra confirmed that the dye was surface bound. The new polymers with covalently attached dye display significant bactericidal activity against Escherichia coli and Staphylococcus epidermidis with a 99.999% reduction in viable bacteria after four minutes exposure to a low power laser.

Graphical abstract: Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface
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