A green alternative approach to the chiral induction of a metal–organic framework (MOF) has been explored using the natural deep eutectic solvents (DES) proline : thymol (1 : 7) and menthol : thymol (1 : 1). These solvents have been successfully employed for the preparation of the MIL-103 MOF and lead to an enantioenrichment of the porous material when used in enantiopure form, as demonstrated by circular dichroism.