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Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli†
Barbara Rohm,Kirstin Scherlach
Organic & Biomolecular Chemistry Pub Date : 02/05/2010 00:00:00 , DOI:10.1039/B925483H
Abstract

Biosynthetic studies with 13C-labelled acetates and methionine revealed that the infamous, food-related toxin bongkrekic acid from Burkholderia gladioli is a polyketide with acetate-derived β-branches and a carboxylate terminus derived from the methyl group of an acetate.

Graphical abstract: Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli
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