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Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation†‡
Zhiyuan Liu,Jonathan L. Sessler,Chuanhu Lei
Chemical Communications Pub Date : 08/26/2020 00:00:00 , DOI:10.1039/D0CC03966G
Abstract

An efficient nickel(II)-catalyzed transfer dehydrogenation oxidation of alcohols is reported that relies on cyclohexanone as the formal oxidant and does not require the use of an external base. The synthetic utility of this protocol is demonstrated via the facile oxidation of structurally complicated natural products.

Graphical abstract: Base-free oxidation of alcohols enabled by nickel(ii)-catalyzed transfer dehydrogenation
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