Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study†,10.1039/C4RA07964G

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Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study†

Vaishali S. Shende,Savita K. Shingote,Sudhindra H. Deshpande,Nishamol Kuriakose,Kumar Vanka,Ashutosh A. Kelkar

RSC Advances Pub Date : 09/08/2014 00:00:00 , DOI:10.1039/C4RA07964G

Abstract

Asymmetric transfer hydrogenation of various cyclic imines proceeded efficiently with water/methanol co-solvent media in 20 min with excellent yields and enantioselectivities by employing Rh–TsDPEN catalyst and sodium formate as a hydrogen donor. The role of the co-solvent in enhanced productivity of the reaction was investigated by DFT. The mechanism for ATH of the imines has been discussed on the basis of the DFT study.