Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs†,10.1039/C9CC09947F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Bioadhesive supramolecular hydrogel from unprotected, short d,l-peptides with Phe-Phe and Leu-Asp-Val motifs†

Maria Cristina Cringoli,Chiara Romano,Evelina Parisi,Lynne J. Waddington,Michele Melchionna,Sabrina Semeraro,Rita De Zorzi,Mikaela Grönholm,Silvia Marchesan

Chemical Communications Pub Date : 01/31/2020 00:00:00 , DOI:10.1039/C9CC09947F

Abstract

The uncapped tripeptide ^DPhe-Phe-Leu acts as self-assembly template to yield supramolecular hydrogel biomaterials. As an example, self-assembling ^DPhe-Phe-Leu-Asp-Val contains the LDV bioadhesive motif for β1 integrin activation. Hydrogels made of the two peptides successfully mimic fibronectin of the extracellular matrix and lead to high cell viability, adhesion, and spreading.