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Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics†
Jia Jia Dong,Julien Roger,Cécile Verrier,Thibaut Martin,Ronan Le Goff,Christophe Hoarau,Henri Doucet
Green Chemistry Pub Date : 10/11/2010 00:00:00 , DOI:10.1039/C0GC00229A
Abstract

The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range of heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. The best yields were obtained using benzoxazole or thiazole derivatives. The arylation of furan, thiophene, pyrrole, imidazole or isoxazole derivatives was found to require a more elevated reaction temperature.

Graphical abstract: Carbonates: eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics
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