Catalyst-free synthesis of novel dimeric β-carboline derivatives via an unexpected [2 + 2 + 2] annulation†,10.1039/C7OB00689F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Catalyst-free synthesis of novel dimeric β-carboline derivatives via an unexpected [2 + 2 + 2] annulation†

Hai-Lei Cui,Jing-Fang Wang,Hai-Lin Zhou,Xiao-Lin You,Xiao-Jie Jiang

Organic & Biomolecular Chemistry Pub Date : 04/12/2017 00:00:00 , DOI:10.1039/C7OB00689F

Abstract

We report here an unexpected catalyst-free [2 + 2 + 2] annulation reaction which allows access to novel complex dimeric β-carboline derivatives in a single step. Various substituted ynones could react with dihydro-β-carboline imines to deliver interesting [2 + 2 + 2] annulation products in moderate to good yields. Alkynoates can also be tolerated in this system.