Catalyst-free tosylation of lipophilic alcohols in water†
Manuela Oliverio,Paola Costanzo,Rosina Paonessa,Monica Nardi,Antonio Procopio
RSC Advances Pub Date : 12/21/2012 00:00:00 , DOI:10.1039/C2RA23067D
Abstract

The first catalyst-free and on-water method for tosylation of alcohols is presented. Tosylation can be realized in a few minutes under microwave-assistance, exploiting the water insolubility of reagents and products as the driving force of the reaction. A biodegradable water solution of p-toluenesulfonic acid is the only waste produced.

Graphical abstract: Catalyst-free tosylation of lipophilic alcohols in water