960化工网
Biomimetic syntheses of C23 terpenoids: structural revision of salyunnanin A and confirmation of hassanane†
Xun Zhang,Zhongle Li,Huaya Yong,Zhixiang Xie
Organic Chemistry Frontiers Pub Date : 10/25/2018 00:00:00 , DOI:10.1039/C8QO00772A
Abstract

Salyunnanin A and hassanane, two C23 terpenoids, were achieved from (+)-carnosic acid in 6 and 5 steps, respectively. The synthetic strategy was primarily inspired by the biogenetic hypothesis and provided access to the natural products via elimination, double Michael-type addition in one pot to prepare the corresponding 6,20-epoxyabietanes, and bismuthonium ylide induced ring expansion of o-quinone to construct 2-acyl-3-hydroxytropone.

Graphical abstract: Biomimetic syntheses of C23 terpenoids: structural revision of salyunnanin A and confirmation of hassanane
平台客服
平台客服
平台在线客服