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Boronic acid-mediated ring-opening and Ni-catalyzed arylation of 1-arylcyclopropyl tosylates†
L. Reginald Mills,John J. Monteith,Sophie A. L. Rousseaux
Chemical Communications Pub Date : 09/30/2020 00:00:00 , DOI:10.1039/D0CC05895E
Abstract

Herein, we describe a protocol for the ring-opening arylation of 1-arylcyclopropyl tosylates, in which boronic acids promote ring-opening and a Ni catalyst facilitates arylation in high regioselectivity. A number of 2-arylated allyl derivatives are synthesized, which are relevant motifs found in biologically active molecules.

Graphical abstract: Boronic acid-mediated ring-opening and Ni-catalyzed arylation of 1-arylcyclopropyl tosylates
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