Asymmetric ring-opening of cyclopropyl ketones with β-naphthols catalyzed by a chiral N,N′-dioxide–scandium(iii) complex†,10.1039/C8QO00016F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Asymmetric ring-opening of cyclopropyl ketones with β-naphthols catalyzed by a chiral N,N′-dioxide–scandium(iii) complex†

Yong Xia,Fenzhen Chang,Lili Lin,Yali Xu,Xiaohua Liu,Xiaoming Feng

Organic Chemistry Frontiers Pub Date : 02/02/2018 00:00:00 , DOI:10.1039/C8QO00016F

Abstract

A catalytic asymmetric ring-opening reaction of cyclopropyl ketones with β-naphthols has been accomplished. In the presence of a chiral N,N′-dioxide/scandium(III) complex, a series of aromatic or vinyl substituted cyclopropyl ketones reacted with 2-naphthols, providing efficient access to chiral β-naphthol derivatives in good yields (up to 99%) with good enantioselectivities (up to 97% ee). Notably, using the mixture of 2-naphthol substrates did not affect the efficiency of this catalytic system.