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Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media†
Ying Zhang,Shun-Yi Wang,Xiao-Ping Xu,Ran Jiang,Shun-Jun Ji
Organic & Biomolecular Chemistry Pub Date : 02/01/2013 00:00:00 , DOI:10.1039/C3OB00045A
Abstract

Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.

Graphical abstract: Asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media
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