Brønsted acid-catalyzed enantioselective Friedländer condensations: achiral amine promoter plays crucial role in the stereocontrol†‡
Lei Ren,Tao Lei,Liu-Zhu Gong
Chemical Communications Pub Date : 09/26/2011 00:00:00 , DOI:10.1039/C1CC14873G
Abstract
A highly enantioselective Friedländer condensation has been established by using chiral Brønsted acids in combination with achiral amines to give quinolines in high yields (up to 99%) and with excellent enantioselectivities (up to 95%).