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Catalyst-and solvent-free one-pot synthesis of some novel polyheterocycles from aryldiazenyl salicylaldehyde derivatives†
Narsidas J. Parmar,Rikin A. Patel,Shashikant B. Teraiya,Deepak Sharma,Vivek K. Gupta
RSC Advances Pub Date : 02/21/2012 00:00:00 , DOI:10.1039/C2RA00930G
Abstract

A catalyst-and solvent-free domino/Knoevenagel-hetero-Diels–Alder (DKHDA) reaction of two aldyhyde substrates, allyl/prenyl ether tethered aryldiazenylsalicylaldehydes with corresponding pyrazolones and heterocyclic 1,3-diketones is described. Subsequent reduction of aryldiazenylpolyheterocycles, thus obtained in high yields (70–86%), afforded analogues amino frameworks with anticipated biological activity. While in a conventional procedure, no reaction was observed without activation of an allyl-based substrate, an excellent yield was achieved at higher temperature. For a prenyl based substrate, however it underwent smoothly to form a desired cyclised product. The stereochemistry of the compound was confirmed by various NMR experiments and a single crystal X-ray diffraction analysis.

Graphical abstract: Catalyst-and solvent-free one-pot synthesis of some novel polyheterocycles from aryldiazenyl salicylaldehyde derivatives
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