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A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C–H amidation of benzoic acids†
Ka-Ho Ng,Fo-Ning Ng,Wing-Yiu Yu
Chemical Communications Pub Date : 10/16/2012 00:00:00 , DOI:10.1039/C2CC36502B
Abstract

An efficient method for synthesis of anthranilic acids by Pd-catalyzed ortho-C–H amidation of benzoic acids is disclosed. The amidation is proposed to proceed by carboxylate-assisted ortho-C–H palladation to form an arylpalladium(II) complex, followed by nitrene insertion to the Pd–C bond.

Graphical abstract: A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C–H amidation of benzoic acids
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