Boiling water-catalyzed neutral and selective N-Boc deprotection†
Jia Wang,Yan-Liang Liang,Jin Qu
Chemical Communications Pub Date : 07/31/2009 00:00:00 , DOI:10.1039/B910239F
Abstract
A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.
