A Cu-catalysed synthesis of substituted 3-methyleneisoindolin-1-one†
Anupal Gogoi,Srimanta Guin,Saroj K. Rout,Ganesh Majji,Bhisma K. Patel
RSC Advances Pub Date : 11/03/2014 00:00:00 , DOI:10.1039/C4RA12782J
Abstract

A Cu(I)-catalysed synthesis of substituted 3-methyleneisoindolin-1-ones using alkynyl acids as an alkyne source has been developed. The reaction involves the decarboxylative cross-coupling of 2-halobenzamides with aryl alkynyl acids, followed by 5-exo-dig heteroannulation. While reactions of 2-iodo benzamides proceeded without a ligand, for 2-bromo substrates, the assistance of a ligand is essential.

Graphical abstract: A Cu-catalysed synthesis of substituted 3-methyleneisoindolin-1-one