A domino desulfurative coupling–acylation–hydration–Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines†
Zhong-Fei Yan,Zheng-Jun Quan,Yu-Xia Da,Zhang Zhang,Xi-Cun Wang
Chemical Communications Pub Date : 09/05/2014 00:00:00 , DOI:10.1039/C4CC05090H
Abstract
A novel method for the synthesis of the polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines through a domino desulfurative coupling–acylation–hydration and Michael addition sequence was established.
![Graphical abstract: A domino desulfurative coupling–acylation–hydration–Michael addition process for the synthesis of polysubstituted tetrahydro-4H-pyrido[1,2-a]pyrimidines](http://hg.y866.cn/compound/lib/scimg/usr/1/C4CC05090H.jpg)
