Chiral Brønsted acid catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with α,β-unsaturated ketones: short access to optically active 2- and 3-substituted indole derivatives,10.1039/C0OB00197J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Chiral Brønsted acid catalyzed asymmetric Friedel–Crafts alkylation reaction of indoles with α,β-unsaturated ketones: short access to optically active 2- and 3-substituted indole derivatives

Tsubasa Sakamoto,Junji Itoh,Keiji Mori,Takahiko Akiyama

Organic & Biomolecular Chemistry Pub Date : 09/28/2010 00:00:00 , DOI:10.1039/C0OB00197J

Abstract

The asymmetric Friedel–Crafts alkylation reaction of indoles with α,β-unsaturated ketones catalyzed by chiral phosphoric acid is reported. A wide range of indoles and 4,7-dihydroindoles were allowed to react with α,β-unsaturated ketones to give the corresponding 1,4-adducts in good to high chemical yields and with excellent enantioselectivities.