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Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum
Nano Convergence ( IF 0 ) Pub Date : 2022-10-31 , DOI: 10.1186/s40580-022-00340-8
GoeunPark,MyoungroLee,JiatongKang,ChulwhanPark,JunhongMin,TaekLee
Following publication of the original article [1], the authors noticed that the repetition texts occurred in Acknowledgement and Funding sections. Hence, the following funding section has been removed from the original publication by publishing this erratum.AcknowledgementsThis work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government (MSIT) (No. 2021R1C1C1005583) and by Korea Environment Industry & Technology Institute (KEITI) through the program for the management of aquatic ecosystem health, funded by Korea Ministry of Environment (MOE) (2020003030001) and by the Chung-Ang University Young Scientist Scholarship in 2020.The original article [1] has been updated.G. Park, M. Lee, J. Kang, C. Park, J. Min, T. Lee, Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum. Nano Convergence 9, 41 (2022). http://doi.org/10.1186/s40580-022-00332-8Article Google Scholar Download referencesAuthor notesGoeun Park and Myoungro Lee contributed equallyAuthors and AffiliationsDepartment of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-Gu, Seoul, 01897, Republic of KoreaGoeun Park, Myoungro Lee, Chulwhan Park & Taek LeeSchool of Integrative Engineering, Chung-Ang University, Heukseok-Dong, Dongjak-Gu, Seoul, 06974, Republic of KoreaJiatong Kang & Junhong MinAuthorsGoeun ParkView author publicationsYou can also search for this author in PubMed Google ScholarMyoungro LeeView author publicationsYou can also search for this author in PubMed Google ScholarJiatong KangView author publicationsYou can also search for this author in PubMed Google ScholarChulwhan ParkView author publicationsYou can also search for this author in PubMed Google ScholarJunhong MinView author publicationsYou can also search for this author in PubMed Google ScholarTaek LeeView author publicationsYou can also search for this author in PubMed Google ScholarCorresponding authorsCorrespondence to Junhong Min or Taek Lee.Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Reprints and PermissionsCite this articlePark, G., Lee, M., Kang, J. et al. Correction to: Selection of DNA aptamer and its application as an electrical biosensor for Zika virus detection in human serum. Nano Convergence 9, 49 (2022). http://doi.org/10.1186/s40580-022-00340-8Download citationPublished: 31 October 2022DOI: http://doi.org/10.1186/s40580-022-00340-8Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative
Correction: Single-step acid-catalyzed synthesis of luminescent colloidal organosilica nanobeads
Nano Convergence ( IF 0 ) Pub Date : 2022-12-09 , DOI: 10.1186/s40580-022-00347-1
PhornsawatBaipaywad,SeongVinHong,JongBaeKim,JangsunHwang,JonghoonChoi,HansooPark,TaejongPaik
Correction: Nano Convergence (2022) 9:12 http://doi.org/10.1186/s40580-022-00303-z Following publication of the original article [1], the author noticed the error in Acknowledgement section. An incorrect grant number was cited in the published version. The grant acknowledged, “NRF-2019R1A4A1028700” should be “NRF-2022R1A4A2000776”. This has been corrected with this erratum.P. Baipaywad, S.V. Hong, J.B. Kim, J. Hwang, J. Choi, H. Park, T. Paik, Single-step acid-catalyzed synthesis of luminescent colloidal organosilica nanobeads. Nano Converg 9, 12 (2022). http://doi.org/10.1186/s40580-022-00303-zArticle CAS Google Scholar Download referencesAuthors and AffiliationsSchool of Integrative Engineering, Chung-Ang University, Seoul, 06974, Republic of KoreaPhornsawat Baipaywad, Seong Vin Hong, Jong Bae Kim, Jangsun Hwang, Jonghoon Choi, Hansoo Park & Taejong PaikBiomedical Engineering Institute, Chiang Mai University, Chiang Mai, 50200, ThailandPhornsawat BaipaywadAuthorsPhornsawat BaipaywadView author publicationsYou can also search for this author in PubMed Google ScholarSeong Vin HongView author publicationsYou can also search for this author in PubMed Google ScholarJong Bae KimView author publicationsYou can also search for this author in PubMed Google ScholarJangsun HwangView author publicationsYou can also search for this author in PubMed Google ScholarJonghoon ChoiView author publicationsYou can also search for this author in PubMed Google ScholarHansoo ParkView author publicationsYou can also search for this author in PubMed Google ScholarTaejong PaikView author publicationsYou can also search for this author in PubMed Google ScholarCorresponding authorsCorrespondence to Hansoo Park or Taejong Paik.Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Reprints and PermissionsCite this articleBaipaywad, P., Hong, S.V., Kim, J.B. et al. Correction: Single-step acid-catalyzed synthesis of luminescent colloidal organosilica nanobeads. Nano Convergence 9, 54 (2022). http://doi.org/10.1186/s40580-022-00347-1Download citationPublished: 09 December 2022DOI: http://doi.org/10.1186/s40580-022-00347-1Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative
Dual-mode SERS-based lateral flow assay strips for simultaneous diagnosis of SARS-CoV-2 and influenza a virus
Nano Convergence ( IF 0 ) Pub Date : 2022-09-02 , DOI: 10.1186/s40580-022-00330-w
MengdanLu,YounjuJoung,ChangSuJeon,SunjooKim,DongeunYong,HyowonJang,SungHyunPyun,TaejoonKang,JaebumChoo
Since COVID-19 and flu have similar symptoms, they are difficult to distinguish without an accurate diagnosis. Therefore, it is critical to quickly and accurately determine which virus was infected and take appropriate treatments when a person has an infection. This study developed a dual-mode surface-enhanced Raman scattering (SERS)-based LFA strip that can diagnose SARS-CoV-2 and influenza A virus with high accuracy to reduce the false-negative problem of the commercial colorimetric LFA strip. Furthermore, using a single strip, it is feasible to detect SARS-CoV-2 and influenza A virus simultaneously. A clinical test was performed on 39 patient samples (28 SARS-CoV-2 positives, 6 influenza A virus positives, and 5 negatives), evaluating the clinical efficacy of the proposed dual-mode SERS-LFA strip. Our assay results for clinical samples show that the dual-mode LFA strip significantly reduced the false-negative rate for both SARS-CoV-2 and influenza A virus.
Effect of vacancies and edges in promoting water chemisorption on titanium-based MXenes
Nano Convergence ( IF 0 ) Pub Date : 2023-04-01 , DOI: 10.1186/s40580-023-00364-8
EdoardoMarquis,FrancescaBenini,BabakAnasori,AndreasRosenkranz,MariaCleliaRighi
The functionality of two-dimensional (2D) transition metal carbides and nitrides (MXenes) in technological applications greatly depends on their wettability. For instance, MXenes’ layer stability against degradative oxidation is notably reduced when stored in aqueous solutions, leading to the transformation into oxides. In this work, we study water adsorption on Ti-based MXenes by ab initio calculations. The energy gains for the molecular adsorption on Tin+1XnT2 is evaluated as a function of the termination (T = F, O, OH, mixture), the carbon/nitrogen ratio (X = C, N), the layer thickness (n) and water coverage. MXenes’ hydrophilicity tends to increase due to the presence of defects as vacancies and flake edges. We demonstrate that physical adsorption occurs through hydrogen bonding on both defect-free layers and layers containing C/N or Ti atomic vacancies, with –OH terminations providing the strongest interactions (0.40–0.65 eV). In contrast, strong water chemisorption is observed on surfaces with a single termination vacancy (0.60–1.20 eV), edges (0.75–0.85 eV), and clusters of defects (1.00–1.80 eV). We verified that the presence of undercoordinated Ti atoms on the surface is the key factor in promoting H2O chemisorption, i.e., the degradative oxidation.
Membrane-wrapped nanoparticles for photothermal cancer therapy
Nano Convergence ( IF 0 ) Pub Date : 2022-08-12 , DOI: 10.1186/s40580-022-00328-4
SaraBAboeleneen,MackenzieAScully,JennaCHarris,EricHSterin,EmilySDay
Cancer is a global health problem that needs effective treatment strategies. Conventional treatments for solid-tumor cancers are unsatisfactory because they cause unintended harm to healthy tissues and are susceptible to cancer cell resistance. Nanoparticle-mediated photothermal therapy is a minimally invasive treatment for solid-tumor cancers that has immense promise as a standalone therapy or adjuvant to other treatments like chemotherapy, immunotherapy, or radiotherapy. To maximize the success of photothermal therapy, light-responsive nanoparticles can be camouflaged with cell membranes to endow them with unique biointerfacing capabilities that reduce opsonization, prolong systemic circulation, and improve tumor delivery through enhanced passive accumulation or homotypic targeting. This ensures a sufficient dose of photoresponsive nanoparticles arrives at tumor sites to enable their complete thermal ablation. This review summarizes the state-of-the-art in cell membrane camouflaged nanoparticles for photothermal cancer therapy and provides insights to the path forward for clinical translation.
Mesoscopic-scale grain formation in HfO2-based ferroelectric thin films and its impact on electrical characteristics
Nano Convergence ( IF 0 ) Pub Date : 2022-11-12 , DOI: 10.1186/s40580-022-00342-6
MasaharuKobayashi,JixuanWu,YoshikiSawabe,SarayaTakuya,ToshiroHiramoto
Ferroelectric memory devices are expected for low-power and high-speed memory applications. HfO2-based ferroelectric is attracting attention for its CMOS-compatibility and high scalability. Mesoscopic-scale grains, of which size is almost comparable to device size, are formed in HfO2-based ferroelectric poly-crystalline thin films, which largely influences electrical characteristics in memory devices. It is important to study the impact of mesoscopic-scale grain formation on the electrical characteristics. In this work, first, we have studied the thickness dependence of the polarization switching kinetics in HfO2-based ferroelectric. While static low-frequency polarization is comparable for different thickness, dynamic polarization switching speed is slower in thin Hf0.5Zr0.5O2 (HZO) capacitors. Based on the analysis using the NLS model and physical characterization, thinner HZO contains smaller grains with orientation non-uniformity and more grain boundaries than thicker HZO, which can impede macroscopic polarization switching. We have also theoretically and experimentally studied the polar-axis alignment of a HfO2-based ferroelectric thin film. While in-plane polar orientation is stable in as-grown HZO, out-of-plane polarization can be dominant by applying electric field, which indicates the transition from in-plane polar to out-of-plane polar orientation in the ferroelectric phase grains. This is confirmed by calculating kinetic pathway using ab-initio calculation.
Self-assembled, hemin-functionalized peptide nanotubes: an innovative strategy for detecting glutathione and glucose molecules with peroxidase-like activity
Nano Convergence ( IF 0 ) Pub Date : 2023-02-04 , DOI: 10.1186/s40580-023-00356-8
SongXiang,XinchengLong,QiuxiaTu,JianFeng,XiaoheZhang,GuangweiFeng,LiLei
Accurately detecting dynamic changes in bioactive small molecules in real-time is very challenging. In this study, a hemin-based peptide assembly was rationally designed for the colorimetric detection of active small molecules. Hemin-functionalized peptide nanotubes were obtained through the direct incubation of hemin (hemin@PNTs) and peptide nanotubes (PNTs) or were coassembled with the heptapeptide Ac-KLVFFAL-NH2 via electrostatic, π–π stacking, and hydrophobic interactions (hemin-PNTs). This new substance is significant because it exhibits the benefits of both hemin and PNTs as well as some special qualities. First, hemin-PNTs exhibited higher intrinsic peroxidase-like activity, which, in the presence of H2O2, could catalyze the oxidation of the substrate 3,3',5,5'-tetramethylbenzidine (TMB) to yield a typical blue solution after 10 min at 25 ℃. Second, hemin-PNTs showed significantly higher activity than that of hemin, PNTs alone, or hemin@PNTs. Hemin-PNTs with a 20.0% hemin content may cooperate to improve catalytic activity. The catalytic activity was dependent on the reaction temperature, pH, reaction time, and H2O2 concentration. The nature of the TMB-catalyzed reaction may arise from the production of hydroxyl radicals. Fluorescence analysis was used to demonstrate the catalytic mechanism. According to this investigation, a new highly selective and sensitive colorimetric technique for detecting glutathione (GSH), L-cysteine, and glucose was established. The strategy demonstrated excellent sensitivity for GSH in the range of 1 to 30 μM with a 0.51 μM detection limit. Importantly, this glucose detection technique, which employs glucose oxidase and hemin-PNTs, is simple and inexpensive, with a 0.1 μM to 1.0 mM linear range and a 15.2 μM detection limit. Because of their low cost and high catalytic activity, hemin-PNTs are an excellent choice for biocatalysts in a diverse range of potential applications, including applications in clinical diagnostics, environmental chemistry, and biotechnology.
Shape-altering flexible plasmonics of in-situ deformable nanorings
Nano Convergence ( IF 0 ) Pub Date : 2023-03-30 , DOI: 10.1186/s40580-023-00358-6
WeiTao,FlorianLaible,AbdelhamidHmima,ThomasMaurer,MonikaFleischer
Nanorings (NRs) with their intrinsic cavities have attracted interest as plasmonic nanoparticles for years, due to the uniform electric field enhancement inside the cavity, lower plasmon damping effects and comparatively high refractive index sensitivities. In the present work, we successfully fabricated a series of Au NR arrays on flexible polydimethylsiloxane substrates by taking advantage of state-of-the-art fabrication methods such as electron beam lithography and wet-etching transfer techniques. In-situ optical measurements on these flexible systems are enabled by implementing a homemade micro-stretcher inside an optical reflection spectroscopy setup. The corresponding dark-field spectra of thin-walled NR arrays exhibit a strong shift to longer wavelengths (i.e., ~ 2.85 nm per 1% strain) under polarization perpendicular to the traction, mainly resulting from the increasing shape deformation of the NRs under strain. Moreover, numerical simulations illustrate that the shifting plasmonic mode has a radially-symmetric charge distribution of the bonding mode and is rather sensitive to the tuning of the NRs’ shape as confirmed by a subsequent in-situ scanning electron microscope characterization. These results explore the possibilities of shape-altering flexible plasmonics for nanoparticles with a cavity and indicate potential applications for plasmonic colors and biochemical sensing in future work.
Polyaniline-based 3D network structure promotes entrapment and detection of drug-resistant bacteria
Nano Convergence ( IF 0 ) Pub Date : 2023-05-27 , DOI: 10.1186/s40580-023-00370-w
YounseongSong,NahyunPark,DaAeJo,JueunKim,DongeunYong,JayeonSong,YooMinPark,SeokJaeLee,YongTaeKim,SungGapIm,BongGillChoi,TaejoonKang,KyoungGLee
Sensitive and accurate capture, enrichment, and identification of drug-resistant bacteria on human skin are important for early-stage diagnosis and treatment of patients. Herein, we constructed a three-dimensional hierarchically structured polyaniline nanoweb (3D HPN) to capture, enrich, and detect drug-resistant bacteria on-site by rubbing infected skins. These unique hierarchical nanostructures enhance bacteria capture efficiency and help severely deform the surface of the bacteria entrapped on them. Therefore, 3D HPN significantly contributes to the effective and reliable recovery of drug-resistant bacteria from the infected skin and the prevention of potential secondary infection. The recovered bacteria were successfully identified by subsequent real-time polymerase chain reaction (PCR) analysis after the lysis process. The molecular analysis results based on a real-time PCR exhibit excellent sensitivity to detecting target bacteria of concentrations ranging from 102 to 107 CFU/mL without any fluorescent signal interruption. To confirm the field applicability of 3D HPN, it was tested with a drug-resistant model consisting of micropig skin similar to human skin and Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (KPC-CRE). The results show that the detection sensitivity of this assay is 102 CFU/mL. Therefore, 3D HPN can be extended to on-site pathogen detection systems, along with rapid molecular diagnostics through a simple method, to recover KPC-CRE from the skin.
Recent trends in vanadium-based SCR catalysts for NOx reduction in industrial applications: stationary sources
Nano Convergence ( IF 0 ) Pub Date : 2022-11-19 , DOI: 10.1186/s40580-022-00341-7
BoraYe,BoraJeong,Myeung-JinLee,TaeHyeongKim,Sam-SikPark,JaeilJung,SeunghyunLee,Hong-DaeKim
Vanadium-based catalysts have been used for several decades in ammonia-based selective catalytic reduction (NH3-SCR) processes for reducing NOx emissions from various stationary sources (power plants, chemical plants, incinerators, steel mills, etc.) and mobile sources (large ships, automobiles, etc.). Vanadium-based catalysts containing various vanadium species have a high NOx reduction efficiency at temperatures of 350–400 °C, even if the vanadium species are added in small amounts. However, the strengthening of NOx emission regulations has necessitated the development of catalysts with higher NOx reduction efficiencies. Furthermore, there are several different requirements for the catalysts depending on the target industry and application. In general, the composition of SCR catalyst is determined by the components of the fuel and flue gas for a particular application. It is necessary to optimize the catalyst with regard to the reaction temperature, thermal and chemical durability, shape, and other relevant factors. This review comprehensively analyzes the properties that are required for SCR catalysts in different industries and the development strategies of high-performance and low-temperature vanadium-based catalysts. To analyze the recent research trends, the catalysts employed in power plants, incinerators, as well as cement and steel industries, that emit the highest amount of nitrogen oxides, are presented in detail along with their limitations. The recent developments in catalyst composition, structure, dispersion, and side reaction suppression technology to develop a high-efficiency catalyst are also summarized. As the composition of the vanadium-based catalyst depends mostly on the usage in stationary sources, various promoters and supports that improve the catalyst activity and suppress side reactions, along with the studies on the oxidation state of vanadium, are presented. Furthermore, the research trends related to the nano-dispersion of catalytically active materials using various supports, and controlling the side reactions using the structure of shaped catalysts are summarized. The review concludes with a discussion of the development direction and future prospects for high-efficiency SCR catalysts in different industrial fields.
Recent progress of eco-friendly manufacturing process of efficient perovskite solar cells
Nano Convergence ( IF 0 ) Pub Date : 2023-06-12 , DOI: 10.1186/s40580-023-00375-5
NayoonKwon,JaeheeLee,MinJaeKo,YoungYunKim,JangwonSeo
Perovskite solar cells (PSCs) have the potential to produce solar energy at a low cost, with flexibility, and high power conversion efficiency (PCE). However, there are still challenges to be addressed before mass production of PSCs, such as prevention from degradation under external stresses and the uniform, large-area formation of all layers. Among them, the most challenging aspect of mass production of PSCs is creating a high-quality perovskite layer using environmentally sustainable processes that are compatible with industry standards. In this review, we briefly introduce the recent progresses upon eco-friendly perovskite solutions/antisolvents and film formation processes. The eco-friendly production methods are categorized into two: (1) employing environmentally friendly solvents for perovskite precursor ink/solution, and (2) replacing harmful, volatile antisolvents or even limiting their use during the perovskite film formation process. General considerations and criteria for each category are provided, and detailed examples are presented, specifically focused on the works have done since 2021. In addition, the importance of controlling the crystallization behavior of the perovskite layer is highlighted to develop antisolvent-free perovskite formation methods.
Transmissible H-aggregated NIR-II fluorophore to the tumor cell membrane for enhanced PTT and synergistic therapy of cancer
Nano Convergence ( IF 0 ) Pub Date : 2023-01-06 , DOI: 10.1186/s40580-022-00352-4
HaoliYu,YuesongWang,YanChen,MengyuanCui,FangYang,PengWang,MinJi
Photothermal therapy (PTT) combined with second near-infrared (NIR-II) fluorescence imaging (FI) has received increasing attention owing to its capacity for precise diagnosis and real-time monitoring of the therapeutic effects. It is of great clinical value to study organic small molecular fluorophores with both PTT and NIR-II FI functions. In this work, we report a skillfully fluorescent lipid nanosystem, the RR9 (RGDRRRRRRRRRC) peptide-coated anionic liposome loaded with organic NIR-II fluorophore IR-1061 and chemotherapeutic drug carboplatin, which is named RRIALP-C4. According to the structural interaction between IR-1061 and phospholipid bilayer demonstrated by molecular dynamics simulations, IR-1061 is rationally designed to possess the H-aggregated state versus the free state, thus rendering RRIALP-C4 with the activated dual-channel integrated function of intravital NIR-II FI and NIR-I PTT. Functionalization of RRIALP-C4 with RR9 peptide endows the specifically targeting capacity for αvβ3-overexpressed tumor cells and, more importantly, allows IR-1061 to transfer the H-aggregated state from liposomes to the tumor cell membrane through enhanced membrane fusion, thereby maintaining its PTT effect in tumor tissues. In vivo experiments demonstrate that RRIALP-C4 can effectively visualize tumor tissues and systemic blood vessels with a high sign-to-background ratio (SBR) to realize the synergistic treatment of thermochemotherapy by PTT synergistically with temperature-sensitive drug release. Therefore, the strategy of enhanced PTT through H-aggregation of NIR-II fluorophore in the tumor cell membrane has great potential for developing lipid nanosystems with integrated diagnosis and treatment function.
Sustainable colorimetric/luminescent sensors enabled by armored lipid nanoparticles
Nano Convergence ( IF 0 ) Pub Date : 2022-09-30 , DOI: 10.1186/s40580-022-00335-5
JinkyuRoh,YongHoCho,DongJuneAhn
In this study, we developed a highly stable polymeric vesicle using a nanosilica-armor membrane to achieve a sustainable colorimetric/luminescent response. The silica armor can be grown directly as ~ 5 nm spherical nanoparticles on the surface of the diacetylene (DA) vesicle with liposomal structure. This can be accomplished via the modified Stöber reaction in pure water on a layer of amine linkers deposited on the vesicles. Once formed, the structural stability of the DA vesicles dramatically increased and remained so even in a dried powder form that could be stored for a period of approximately 6 months. Then, redispersed in water, the armored vesicles did not agglomerate because of the electric charge of the silica armor. After polymerization, the polydiacetylene (PDA) vesicles maintained an average of 87.4% their sensing capabilities compared to unstored vesicles. Furthermore, the silica membrane thickness can be controlled by reiteration of the electrostatic layer-by-layer approach and the direct hydrolysis of silica. As the number of silica armor membranes increases, the passage of the stimuli passing through the membranes becomes longer. Consequently, three layers of silica armor gave the PDA vesicles size-selective recognition to filter out external stimuli. These discoveries are expected to have large-scale effects in the chemo- and biosensor fields by applying protective layers to organic nanomaterials.
Accurate delivery of pristimerin and paclitaxel by folic acid-linked nano-micelles for enhancing chemosensitivity in cancer therapy
Nano Convergence ( IF 0 ) Pub Date : 2022-11-24 , DOI: 10.1186/s40580-022-00343-5
ChaoChen,ShiyuDu,WuZhong,KunguoLiu,LihuaQu,FeiyiChu,JingjingYang,XinHan
Chemoresistance remains a huge challenge for effective treatment of non-small cell lung cancer (NSCLC). Previous studies have shown Chinese herbal extracts possess great potential in ameliorating tumor chemoresistance, however, the efficacy is clinically limited mainly because of the poor tumor-targeting and in vivo stability. The construction of nano-delivery systems for herbal extracts has been shown to improve drug targeting, enhance therapeutic efficacy and reduce toxic and side effects. In this study, a folic acid (FA)-modified nano-herb micelle was developed for codelivery of pristimerin (PRI) and paclitaxel (PTX) to enhance chemosensitivity of NSCLC, in which PRI could synergistically enhance PTX-induced growth inhibition of A549 cancer cell. PTX was firstly grafted with the FA-linked polyethylene glycol (PEG) and then encapsulated with PRI to construct the PRI@FA-PEG-PTX (P@FPP) nano-micelles (NMs), which exhibited improved tumor-targeting and in vivo stability. This active-targeting P@FPP NMs displayed excellent tumor-targeting characteristics without obvious toxicity. Moreover, inhibition of tumor growth and metastasis induced by P@FPP NMs were significantly enhanced compared with the combined effects of the two drugs (PRI in combination of PTX), which associated with epithelial mesenchymal transition inhibition to some extent. Overall, this active-targeting NMs provides a versatile nano-herb strategy for improving tumor-targeting of Chinese herbal extracts, which may help in the promotion of enhancing chemosensitivity of NSCLC in clinical applications.
Anisotropy of impact ionization in WSe2 field effect transistors
Nano Convergence ( IF 0 ) Pub Date : 2023-03-17 , DOI: 10.1186/s40580-023-00361-x
TaehoKang,HaejuChoi,JinshuLi,ChanwooKang,EuyheonHwang,SungjooLee
Carrier multiplication via impact ionization in two-dimensional (2D) layered materials is a very promising process for manufacturing high-performance devices because the multiplication has been reported to overcome thermodynamic conversion limits. Given that 2D layered materials exhibit highly anisotropic transport properties, understanding the directionally-dependent multiplication process is necessary for device applications. In this study, the anisotropy of carrier multiplication in the 2D layered material, WSe2, is investigated. To study the multiplication anisotropy of WSe2, both lateral and vertical WSe2 field effect transistors (FETs) are fabricated and their electrical and transport properties are investigated. We find that the multiplication anisotropy is much bigger than the transport anisotropy, i.e., the critical electric field (ECR) for impact ionization of vertical WSe2 FETs is approximately ten times higher than that of lateral FETs. To understand the experimental results we calculate the average energy of the carriers in the proposed devices under strong electric fields by using the Monte Carlo simulation method. The calculated average energy is strongly dependent on the transport directions and we find that the critical electric field for impact ionization in vertical devices is approximately one order of magnitude larger than that of the lateral devices, consistent with experimental results. Our findings provide new strategies for the future development of low-power electric and photoelectric devices.
Applications of remote epitaxy and van der Waals epitaxy
Nano Convergence ( IF 0 ) Pub Date : 2023-04-30 , DOI: 10.1186/s40580-023-00369-3
IlpyoRoh,SeokHyeonGoh,YuanMeng,JustinSKim,SangmoonHan,ZhihaoXu,HanEolLee,YeonginKim,Sang-HoonBae
Epitaxy technology produces high-quality material building blocks that underpin various fields of applications. However, fundamental limitations exist for conventional epitaxy, such as the lattice matching constraints that have greatly narrowed down the choices of available epitaxial material combinations. Recent emerging epitaxy techniques such as remote and van der Waals epitaxy have shown exciting perspectives to overcome these limitations and provide freestanding nanomembranes for massive novel applications. Here, we review the mechanism and fundamentals for van der Waals and remote epitaxy to produce freestanding nanomembranes. Key benefits that are exclusive to these two growth strategies are comprehensively summarized. A number of original applications have also been discussed, highlighting the advantages of these freestanding films-based designs. Finally, we discuss the current limitations with possible solutions and potential future directions towards nanomembranes-based advanced heterogeneous integration.
Biomimetic anti-inflammatory and osteogenic nanoparticles self-assembled with mineral ions and tannic acid for tissue engineering
Nano Convergence ( IF 0 ) Pub Date : 2022-10-10 , DOI: 10.1186/s40580-022-00338-2
HayeonByun,GyuNamJang,Min-HoHong,JiwonYeo,HyunjungShin,WonJongKim,HeungsooShin
Bone healing involves complex processes including inflammation, induction, and remodeling. In this context, anti-inflammatory and osteoconductive multi-functional nanoparticles have attracted considerable attention for application in improved bone tissue regeneration. In particular, nanoparticles that promote suppression of inflammatory response after injury and direction of desirable tissue regeneration events are of immense interest to researchers. We herein report a one-step method to prepare multi-functional nanoparticles using tannic acid (TA) and simulated body fluid (SBF) containing multiple mineral ions. Mineral-tannic acid nanoparticles (mTNs) were rapidly fabricated in 10 min, and their size (around 250–350 nm) and chemical composition were controlled through the TA concentration. In vitro analysis using human adipose derived stem cells (hADSCs) showed that mTNs effectively scavenged reactive oxygen species (ROS) and enhanced osteogenesis of hADSCs by inducing secretion of alkaline phosphatase. mTNs also increased osteogenic marker gene expression even in the presence of ROS, which can generally arrest osteogenesis (OPN: 1.74, RUNX2: 1.90, OCN: 1.47-fold changes relative to cells not treated with mTNs). In vivo analysis using a mouse peritonitis model revealed that mTNs showed anti-inflammatory effects by decreasing levels of pro-inflammatory cytokines in blood (IL-6: 73 ± 4, TNF-α: 42 ± 2%) and peritoneal fluid (IL-6: 78 ± 2, TNF-α: 21 ± 6%). We believe that this one-step method for fabrication of multi-functional nanoparticles has considerable potential in tissue engineering approaches that require control of complex microenvironments, as required for tissue regeneration.
Bolstering the secretion and bioactivities of umbilical cord MSC-derived extracellular vesicles with 3D culture and priming in chemically defined media
Nano Convergence ( IF 0 ) Pub Date : 2022-12-19 , DOI: 10.1186/s40580-022-00349-z
JunYongKim,Won-KyuRhim,Seung-GyuCha,JiwonWoo,JooYounLee,ChunGwonPark,DongKeunHan
Human mesenchymal stem cells (hMSCs)-derived extracellular vesicles (EVs) have been known to possess the features of the origin cell with nano size and have shown therapeutic potentials for regenerative medicine in recent studies as alternatives for cell-based therapies. However, extremely low production yield, unknown effects derived from serum impurities, and relatively low bioactivities on doses must be overcome for translational applications. As several reports have demonstrated the tunability of secretion and bioactivities of EVs, herein, we introduced three-dimensional (3D) culture and cell priming approaches for MSCs in serum-free chemically defined media to exclude side effects from serum-derived impurities. Aggregates (spheroids) with 3D culture dramatically enhanced secretion of EVs about 6.7 times more than cells with two-dimensional (2D) culture, and altered surface compositions. Further modulation with cell priming with the combination of TNF-α and IFN-γ (TI) facilitated the production of EVs about 1.4 times more than cells without priming (9.4 times more than cells with 2D culture without priming), and bioactivities of EVs related to tissue regenerations. Interestingly, unlike changing 2D to 3D culture, TI priming altered internal cytokines of MSC-derived EVs. Through simulating characteristics of EVs with bioinformatics analysis, the regeneration-relative properties such as angiogenesis, wound healing, anti-inflammation, anti-apoptosis, and anti-fibrosis, for three different types of EVs were comparatively analyzed using cell-based assays. The present study demonstrated that a combinatory strategy, 3D cultures and priming MSCs in chemically defined media, provided the optimum environments to maximize secretion and regeneration-related bioactivities of MSC-derived EVs without impurities for future translational applications.
Colloidal inorganic nano- and microparticles for passive daytime radiative cooling
Nano Convergence ( IF 0 ) Pub Date : 2023-04-18 , DOI: 10.1186/s40580-023-00365-7
HoYoungWoo,YoonjooChoi,HyesunChung,DaWonLee,TaejongPaik
Compared to traditional cooling systems, radiative cooling (RC) is a promising cooling strategy in terms of reducing energy consumption enormously and avoiding severe environmental issues. Radiative cooling materials (RCMs) reduce the temperature of objects without using an external energy supply by dissipating thermal energy via infrared (IR) radiation into the cold outer space through the atmospheric window. Therefore, RC has a great potential for various applications, such as energy-saving buildings, vehicles, water harvesting, solar cells, and personal thermal management. Herein, we review the recent progress in the applications of inorganic nanoparticles (NPs) and microparticles (MPs) as RCMs and provide insights for further development of RC technology. Particle-based RCMs have tremendous potential owing to the ease of engineering their optical and physical properties, as well as processibility for facile, inexpensive, and large area deposition. The optical and physical properties of inorganic NPs and MPs can be tuned easily by changing their size, shape, composition, and crystals structures. This feature allows particle-based RCMs to fulfill requirements pertaining to passive daytime radiative cooling (PDRC), which requires high reflectivity in the solar spectrum and high emissivity within the atmospheric window. By adjusting the structures and compositions of colloidal inorganic particles, they can be utilized to design a thermal radiator with a selective emission spectrum at wavelengths of 8–13 μm, which is preferable for PDRC. In addition, colloidal particles can exhibit high reflectivity in the solar spectrum through Mie-scattering, which can be further engineered by modifying the compositions and structures of colloidal particles. Recent advances in PDRC that utilize inorganic NPs and MPs are summarized and discussed together with various materials, structural designs, and optical properties. Subsequently, we discuss the integration of functional NPs to achieve functional RCMs. We describe various approaches to the design of colored RCMs including structural colors, plasmonics, and luminescent wavelength conversion. In addition, we further describe experimental approaches to realize self-adaptive RC by incorporating phase-change materials and to fabricate multifunctional RC devices by using a combination of functional NPs and MPs.
Correction: Investigation of the mechanism of the anomalous Hall effects in Cr2Te3/(BiSb)2(TeSe)3 heterostructure
Nano Convergence ( IF 0 ) Pub Date : 2023-02-20 , DOI: 10.1186/s40580-023-00360-y
SeongWonCho,InHakLee,YoungwoongLee,SangheonKim,YeongGwangKhim,Seung-YoungPark,YounghunJo,JunwooChoi,SeungwuHan,YoungJunChang,SuyounLee
Correction: Nano Convergence (2023) 10:2 http://doi.org/10.1186/s40580-022-00348-0 Following publication of the original article [1], the author noticed an error in the corresponding authorship of the article. The typesetter has inadvertently missed to include co-corresponding authorship to Young Jun Chang at the time of correction process. This has been corrected with this erratum.S.W. Cho, I.H. Lee, Y. Lee, S. Kim, Y.G. Khim, S.Y. Park, Y. Jo, J. Choi, S. Han, Y.J. Chang, S. Lee, Investigation of the mechanism of the anomalous Hall effects in Cr2Te3/(BiSb)2 (TeSe)3 heterostructure. Nano Convergence 10, 2 (2023). http://doi.org/10.1186/s40580-022-00348-0Article CAS Google Scholar Download referencesAuthor notesSeong Won Cho and In Hak Lee contributed equally to this workAuthors and AffiliationsCenter for Neuromorphic Engineering, Korea Institute of Science and Technology, Seoul, 02792, KoreaSeong Won Cho, Youngwoong Lee, Sangheon Kim & Suyoun LeeDepartment of Materials Science and Engineering, Seoul National University, Seoul, 08826, KoreaSeong Won Cho & Seungwu HanCenter for Spintronics, Korea Institute of Science and Technology, Seoul, 02792, KoreaIn Hak Lee & Junwoo ChoiDepartment of Physics, Konkuk University, Seoul, 05029, KoreaYoungwoong LeeDepartment of Materials Science and Engineering, Korea University, Seoul, 02841, KoreaSangheon KimDepartment of Physics, University of Seoul, Seoul, 02504, KoreaYeong Gwang Khim & Young Jun ChangDepartment of Smart Cities, University of Seoul, Seoul, 02504, KoreaYeong Gwang Khim & Young Jun ChangCenter for Scientific Instrumentation, Korea Basic Science Institute, Daejeon, 34133, KoreaSeung-Young Park & Younghun JoDivision of Nano & Information Technology, Korea University of Science and Technology, Daejeon, 34316, KoreaSuyoun LeeAuthorsSeong Won ChoView author publicationsYou can also search for this author in PubMed Google ScholarIn Hak LeeView author publicationsYou can also search for this author in PubMed Google ScholarYoungwoong LeeView author publicationsYou can also search for this author in PubMed Google ScholarSangheon KimView author publicationsYou can also search for this author in PubMed Google ScholarYeong Gwang KhimView author publicationsYou can also search for this author in PubMed Google ScholarSeung-Young ParkView author publicationsYou can also search for this author in PubMed Google ScholarYounghun JoView author publicationsYou can also search for this author in PubMed Google ScholarJunwoo ChoiView author publicationsYou can also search for this author in PubMed Google ScholarSeungwu HanView author publicationsYou can also search for this author in PubMed Google ScholarYoung Jun ChangView author publicationsYou can also search for this author in PubMed Google ScholarSuyoun LeeView author publicationsYou can also search for this author in PubMed Google ScholarCorresponding authorsCorrespondence to Young Jun Chang or Suyoun Lee.Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Reprints and PermissionsCite this articleCho, S.W., Lee, I.H., Lee, Y. et al. Correction: Investigation of the mechanism of the anomalous Hall effects in Cr2Te3/(BiSb)2(TeSe)3 heterostructure. Nano Convergence 10, 11 (2023). http://doi.org/10.1186/s40580-023-00360-yDownload citationPublished: 20 February 2023DOI: http://doi.org/10.1186/s40580-023-00360-yShare this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a shareable link is not currently available for this article.Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative
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