An organic–inorganic hybrid Pb(II)-based 1D coordination polymer, {[Pb(NSB)NO3.DMF]}n (CP) (H-NSB = isonicotinic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide; DMF = N,N-dimethylformamide), is structurally characterized by single crystal X-ray diffraction measurement and other spectroscopic data. The structure shows that the ligand, H-NSB serves as a monoanionic tetradentate N2O2 chelating linker of μ3-κN,κO;κO,N,O type, where κO (phenolato-O) brings two Pb(II) centres together and the tridentate NO2 unit chelates (κO,N,O) with one Pb(II) unit followed by its pyridyl-N links (κN) with nearest Pb(II) centre for propagating as a seven coordinated distorted pentagonal bi-pyramidal PbO5N2 core (one O donor comes from DMF and another O from NO3−). Thus, 1D chain is constructed that is thermally stable. The noncovalent interactions (π…π, H-bonding and C-H…π) amongst the 1D chains make supramolecular 3D architecture. The Hirshfeld surface analysis approves the existence of several noncovalent interactions for the formation of 3D network. The reasonable band gap of 3.04 eV for the CP lies in the semiconducting region, which simulates fabrication of photoelectrochemical device with high magnitude of photocurrent (current density: ~2.5 μA cm−2). Mott–Schottky analysis indicates the n-type semiconducting behaviour, and chronoamperometry plot also shows the stability of the material against photo corrosion. Present elucidation would decipher an encouraging pathway for harvesting next-generation energy resources based on a novel Pb(II)-naphthyl-isonicotinohydrazide Schiff base-based CP.

A new neutral dimeric Ar-BIAN Cu(I) complex (where Ar-BIAN = bis(aryl-imino)acenaphthene) of formulation [CuBr(4-iPrC6H4-BIAN)]2 (2) was obtained by reacting CuBr and ligand 4-iPrC6H4-BIAN (L2) in refluxing acetonitrile under an argon atmosphere. When the ligand used was 2,4,6-Me3C6H2-BIAN (L1), we obtained 1 in which the expected dimer (1a) is present, but we could also observe, in solution, the presence of the bis-chelate dimer [Cu(2,4,6-Me3C6H2-BIAN)2][CuBr2] (1b) bearing CuBr2− as counter-ion; attempts to separate them failed. When the ligand used was 2-iPrC6H4-BIAN (L3), we obtained 3 in which the expected dimer (3a) is in equilibrium, in solution, with its bis-chelate isomer [Cu(2-iPrC6H4-BIAN)2][CuBr2] (3b). The solid-state molecular structures of compounds 2 and 3b were determined by single crystal X-ray diffraction. The electrochemical behaviour of complexes: 1 (1a, and 1b), 2, and 3 (3a and 3b) and the known compound [Cu(2-iPrC6H4-BIAN)2][BF4] (7) were investigated by cyclic voltammetry. The new complexes 1 (1a, 1b), 2, and 3 (3a, 3b) were tested as catalysts for the aerobic oxidation of benzylic alcohols into aldehydes; they all catalyse the reaction, with good results; the catalytic studies were extended to the similar known complexes [CuBr(2,6-iPr2C6H3-BIAN)]2 (4), [CuI(2,6-iPr2C6H3-BIAN)]2 (5), [CuCl(2,6-iPr2C6H3-BIAN)]2 (6) and (7), in order to study the effect of different bridging halides or counter ions in the catalytic activity. We found that compound 4 exhibited a high catalytic activity comparable to the best results published so far. The oxidation products, benzaldehydes, were detected and further confirmed by NMR spectroscopy, and the conversion rate was determined after GC-FID analysis.

The built-in electric field induced by piezoelectric effect for suppressing the electron–hole recombination has gained substantial attention recently. In this study, a novel Z-scheme ZnSnO3/Bi2WO6 (ZSO/BWO) piezo-photocatalyst with synergistic polarized electric field was synthesized by a simple impregnation method. The optimized 1% ZSO/BWO shows high piezo-photodegradation efficiency (99.9%, 60 min) and mineralization (42%, 60 min) of diclofenac (DCF) under the synergistic action of ultrasound and light, far exceeding that under sole ultrasound or illumination. The remarkable enhanced piezo-photocatalytic activity of ZSO/BWO composite was attributed to the increased absorption, improved charge transfer, Z-scheme heterojunction, and tight surface contact between ZSO and BWO. Moreover, the Z-scheme mechanism of ZSO/BWO composites is studied in depth and confirmed by the free radical capture experiment and electron spin resonance technology. In addition, the corresponding intermediates of DCF degradation and the possible degradation pathways that were proposed on ZSO/BWO composites were analyzed by liquid chromatography–mass spectrometry and DFT. This work offers an efficient approach for constructing and preparing the highly efficient piezo-photocatalysts for converting solar and mechanical vibration energies.

A couple of N-(4)-morpholine/pyrrolidine-substituted thiosemicarbazones (TSCs) of fluorene-2-carboxaldehyde (FM and FP), and their corresponding thiadiazoles (TDZs) (CFM and CFP), were synthesized and characterized (elemental analysis, ultraviolet–visible [UV–Visible], Fourier transform infrared [FT-IR], nuclear magnetic resonance [NMR; 1H & 13C], high-resolution mass spectrometry [HRMS], and single-crystal X-ray diffraction [SCXRD]) for the evaluation of their anticancer potential. The TDZs were obtained unexpectedly and are possibly formed via single-step metal (copper)-mediated oxidative cyclizations of the TSCs. The synthesized compounds are fairly stable in phosphate buffer at the biological pH of 7.4. The density functional theory [DFT] studies were performed to predict the optimized structures and physicochemical properties of these compounds. The compounds were further subjected to computational and experimental biomolecular investigations in order to evaluate their anticancer activity in detail. CFM had the most potent activity against human breast adenocarcinoma (MCF-7) and human urinary bladder (T24) cancer cells, with IC50 values of 12.00 and 24.80 μM, respectively. In contrast, CFM had negligible cytotoxicity (IC50 = 98.70 μM) against kidney epithelial cells extracted from an African green monkey (Vero) normal cells. This outcome was preferable to that of the widely used medicine Cisplatin. Molecular docking studies were performed with the breast cancer protein “cytochrome P450 1A1” (CYP1A1) and bovine serum albumin (BSA) to predict how effectively the compounds bind to the receptor. The ADMET findings suggest that these compounds have considerable drug-likeness and oral bioavailability. These insights may open the door for additional medical research into the bioactivities of TSCs and TDZs produced from bioactive carbonyl compounds.

A series of manganese(I) tricarbonyl complexes formulated as [Mn(8-HQ)(CO)3Imd] (HQ = hydroxyquinoline and Imd = imidazole derivatives) was synthesized and fully characterized. These structures could be easily accessed from a common dimeric edifice formulated as [Mn2(8-HQ)2(CO)6]. The structure of this complex has been confirmed by X-ray diffraction studies. Its reaction with a range of imidazole derivatives (Imd) yielded the monomeric complexes [Mn(8-hydroxyquinoline)(CO)3Imd] with various functional groups as an anchoring point for a vector. Photoactivation of all these complexes by blue-light irradiation led to the liberation of 3 mol of CO per mol of complex as determined experimentally. Spectroscopic and computational methods were employed to explore the mechanism of CO release. Finally, a manganese complex including the more elaborate imidazole ligand N- and C-di-protected histidine was successfully synthesized, opening the way to its direct incorporation in peptides.

The synthesis of a simple, highly tunable, and effective BSI ligand, 2-(benzothiazol-2-ylimino)-2,3-dihydro-1H-imidazol-4-ol, was presented. Three new coordinating substances of BSI ligand were synthesized. Various spectroscopic and analytical methods, including 1H NMR and 13C NMR, infrared (IR), ultraviolet–visible (UV-vis), thermal conduction, and measures of magnetism, were used to clarify the structures of these compounds. A further examination of the compounds revealed an octahedral-coordinating environment surrounding the Fe3+ ion, ([Fe(BSI)2(NO3)2](NO3·0.5H2O)) and Ni2+, ([Ni(BSI)2(NO3)2](H2O)2) cations and distorted square planner surrounding Pd2+, ([Pd(BSI)(COOCH3)2]H2O) cation. The cations under investigation were linked to the BSI ligand through the nitrogen of the thiazole ring and NH of the imidazole ring. The formed BSI complexes' thermal deterioration behavior was investigated. Calculated kinetic data for the examined complexes' various phases of deterioration supported their endothermic character. Using the Gaussian 09 software at the B3LYP/LANL2DZ level, the equilibrium geometry of the ligands and their coordination complex has been studied by calculations using density functional theory (DFT). The suggested structures by DFT calculation are in good agreement with experimental data. The antibacterial effectiveness of the examined molecules against different types of bacteria and fungus reveals that the BSIPd complex (MIC = 2.25–4.75 μg/mL) has the greatest activity and is most comparable to the standard. The newly synthesized compounds were also tested against several cell lines using the MTT assay. The results are given as an IC50 value, where the Pd(II) complex values show the potential anticancer properties of the compound. Moreover, the inspected complexes showed significant cell growth inhibition activity (IC50 = 6.79–9.05 μg/mL), even higher than the standard anticancer drugs; cisplatin (IC50 = 18 μg/mL) versus breast carcinoma cells. This intriguing finding was verified by Swiss-ADME and pharmacophore query calculations. In accordance with the actual findings, the in silico results showed that the free ligand's low activity increased when it complexed with the inspected metal ions.

The Ag(I) and Cu(II) complexes of the ligand, 2,2′-(1,2,4-oxadiazole-3,5-diyl) dianiline, (L; 4) were synthesized and characterized using different spectroscopic techniques. Their anticancer activities against three types of cancer cell lines were explored. The [AgL (NO3)]n complex (5) has 1D polymeric structure whereas the [CuL (NO3)2] (6) and [CuLCl2] (7) are monomeric complexes. The Ag(I) in 5 is tetra-coordinated and has AgN2O2 coordination sphere where both L and NO3¯ are bridging the Ag(I) sites along the polymer array. In 6 and 7, the coordination environments are CuN3O3 and CuN3Cl2, respectively. In both cases, the oxadiazole ligand is a tridentate chelate via two N-atoms from both amino groups and one N-atom from the oxadiazole moiety. Hirshfeld analysis revealed the importance of O … H (23.5%), H … H (24.8%), and C … C (6.6%) non-covalent interactions in the molecular packing of 5. In 6, the O … H (40.7%), N … H (4.9%), O … O (5.9%), N … O (3.2%), and C … N (2.2%) contacts are the most important. Regarding safety on normal human fibroblasts Wi-38, MTT assay for all metal complexes especially the Ag(I) complex 5 exhibited higher safety profiles than the free oxadiazole ligand as well as the standard chemotherapeutic drug 5-fluroruracil (5-FU). The cytotoxic activities of complexes 5–7 surpassed 5-FU against A549, Caco-2, and MDA-MB231 cell lines. 5 has the best anticancer activity (IC50 = 0.074, 0.085, and 0.533 μM, respectively) and exhibiting pronounced selectivity index up to 44.3. Quantitative PCR analysis of BAX and BCL-2 revealed their apoptotic induction mechanism and showed that the metal complexes can repress the main oncogene BCL-2 and enhance the expression of proapoptotic gene BAX. Again, 5 is the most potent with 14.28 folds BCL-2 downregulation and 4.86 folds BAX upregulation.

The application of coumarin probes as chemosensors for the detection of various species has been broadly explored in recent ages because of their exclusive optical photophysical presentation. The present review especially emphasizes the mechanism involved in the recognition of various vital species through coumarin probes and highlights the current developments in the design of such types of coumarin chemosensors. We also draw attention to the application of the concern protocol and shortfalls of reported coumarin-based fluorescent probes and express our standpoint on future progress in this arena. We are optimistic that the present review can be explored not only as a reference guide for novices but conjointly as a compass of these fields and contribute to cracking more brilliant and meaningful moieties for biological and chemical researchers.

Two new gold(III) complexes, [AuL1]Cl3, A, and [AuL2]Cl3, B, were synthesized and characterized. DFT calculations showed square planar geometry for both complexes. Antioxidant results showed that the ability of compounds to inhibit DPPH• is as follows: A > B > L2 > L1. The anticancer assay showed that both complexes have the ability to inhibit the growth of HCT116 colon cancer cell lines, but B shows a relatively better effect than cisplatin. The interaction effects of A and B on the activity and structure of the bovine liver catalase (BLC) were investigated by spectroscopic techniques and molecular docking. Both complexes were able to change the performance and structure of BLC; B has a greater effect on BLC activity, so at concentration of 2 μM, A and B inhibit initial BLC activity by 92.2% and 55.6%, respectively. The interaction mechanism of A and B with BLC was also different; A interacted mostly with van der Waals interactions and hydrogen bonds, but the most important forces for B was hydrophobic interactions. According to docking results, both complexes prefer the domain III of BLC, but B has higher affinity toward BLC than A, which supports the results of spectroscopic and FMO analysis.

A high-performance catalyst, RuO4@C, was safely generated in situ from a safety mask Ru@C, which was recyclable and commercially available. The catalyst could selectively oxidize thioethers to sulfones in 95%–99% yields and alkynyl sulfurs to alkynylsulfones in 93%–98% yields. This safe, non-toxic, inexpensive, and readily available catalyst is potentially promising for industrial applications in the production of sulfones from sulfur oxidation.

Exploring the potential of silver metal organic frameworks (Ag-MOF), we modified it with sulfanilamide (Ag-MOF-NH2) to create an efficient means for the adsorption of amoxicillin (AMX) from aqueous solutions. We characterized this new material with various imaging and analyzation techniques. Investigations into adsorption were conducted with varying solution pH, contact time, and adsorbent dosages. Moreover, the kinetics and adsorption isotherms were also tested by different models. Results revealed that equilibrium was reached between the antibiotic and the adsorbents within 100 min, with 1.93 and 2.63 mmol·g−1 as the maximum adsorption capacities of Ag-MOF and Ag-MOF-NH2, respectively. The adsorption of AMX onto the adsorbents is closely in line with the pseudo-second-order kinetic model, intraparticle-diffusion model, and Langmuir isotherm, suggesting that the surface of the adsorbent is homogeneous and that the highest binding sites are filled first. By utilizing this data, an engaging conclusion can be drawn: the process of adsorption is efficient and effective. Optimizing adsorption results with Box–Behnken design (BBD) and Response Surface Methodology (RSM) produced impressive outcomes. Additionally, experiments were conducted on non-buffered AMX solutions at various NaNO3 concentrations to ascertain the influence of the electrolytes' composition. Surprisingly, its capacity to take up the element was affected by different concentrations and has ability to be reused several times by capacity above 80% for up to four cycles. Discovering the intricate mechanisms behind AMX adsorption, such as electrostatic forces, π–π interactions, H-bonding, and pore filling, proves to be an invaluable asset in reducing its concentration from real water samples. The mighty potential of Ag-MOF and Ag-MOF-NH2 makes them excellent adsorbents with removal efficiencies ranging between 86% and 97% making them ideal for industrial uses and protecting our environment.

Herein, an affordable, sensitive, and accurate potentiometric method based on a modified carbon paste electrode (MCPE) incorporating 2,2′-(ethane-1,2-diylbis (sulfanediyl)) dianiline, as a selective ionophore, has been introduced for the determination of Cu(II) ions concentration in different real samples. The developed MCPE has a high sensitivity for Cu(II) ions within a wide concentration range from 1.0 × 10−7 to 5.0 × 10−3 mol L−1, a low limit of detection value (LOD) of 5.6 × 10−8 mol L−1, and a Nernstian slope of 29.4 ± 0.28 mV/decade. Furthermore, the developed sensor has a rapid response time (24 s), can work successfully in a wide pH range of 4.5–7.0, and is highly selective to Cu(II) ions over many other cations. The proposed sensor's external surface was scrutinized by the scanning electron microscope (SEM) and energy dispersive X-ray analysis (EDX). Finally, the optimized MCPE was successfully applied for the determination of Cu(II) ions content in different soil samples. Moreover, our MCPE is the first potentiometric sensor applied for the monitoring of the release of Cu(II) ions from one of the commercially available unlined copperware after exposure to food simulants under different conditions. The results were in agreement with those of the inductively coupled plasma (ICP) technique.

The objective of the present study is to develop predictive models to input and output parameters for linear styrene dimerization reactions. These reactions involve the conversion of two styrene molecules into 1,3-diphenyl-1-butene, which is a commonly used intermediate in the production of various industrial chemicals. Multiple linear regression (MLR) and artificial neural network based on multilayer perceptron (MLP) and radial basis function were used to model 1,3-diphenyl-1-butne dimerization process in order to evaluate its performance. The neural network has been trained and tested by experimental data. The effect of various parameters (such as complex concentration) on styrene conversion (Conv%) and turnover of frequency (TOF) has been investigated in the proposed work. The results found by the proposed predictive models were analyzed and compared with the experimental results. Based on the comparison of the results, the radial basis function neural network (RBFNN) model outperformed the other models (MLR and MLP) with a correlation coefficient of (0.987 for Conv% and 0.947 for TOF) and lower root mean square errors for the output parameters. This result demonstrates that the RBFNN is an efficient technique to predict the styrene conversion and turnover frequency of the dimerization reaction. It was exposed that the control strategies learned are robust and can be transferred to similar dimerization reaction configurations.

Two bimetallic homoleptic complexes (CuL1 and CuL2) were synthesized from the coordination of Cu+/2+ ions with diisatin oxalyldihydrazone ligand (H2Lx), respectively. Confirmation of their chemical structures was based on the investigation of alternative spectroscopic tools. To distinguish the role of Cu+/2+ ion and its various charges on their complexes' reactivity, the bioreactivity of H2Lx, CuL1, and CuL2 was established on the spectral results against the growth of some microbial series (fungi and bacteria) and against three human cancer/normal cells. Furthermore, their behavior towards calf thymus DNA (ctDNA) was evaluated through viscometric and spectrophotometric titration. Both CuL1 and CuL2 complexes exhibited an amazing inhibiting effect against the growth of the titled microbial series and the human cancer cells, corresponded to the inhibited zone (mm), MIC (μM), and IC50 magnitudes (μM) and compared with those of their uncoordinated H2Lx ligand. CuL1 demonstrated a featured interacted behavior against ctDNA over that of CuL2 depending on the obtained intrinsic binding constants and the derived Gibbs' free energy values. The assigned nature of interaction could be built on the covalent and/or noncovalent modes, which supported by the electronegativity and electrophilicity of the titled studied compounds towards ctDNA.

Metal-porphyrin complexes with a well-defined M-N4 structure are a class of electrocatalyst materials that can be reasonably designed to exhibit high electrochemical carbon dioxide reduction (CO2RR) performance. The substituent effect of metal-porphyrin complexes plays an important role in CO2RR. Herein, Co-porphyrins with different substituents of -COOCH3, -OCH3, -COOH, and -OH (denoted as CoTCMePP, CoTOMePP, CoTCPP, and CoTOPP) were prepared and uniformly anchored on carbon nanotubes. CoTCMePP/CNTs exhibited a higher FE (CO) of 94.5% with a current density of 12.9 mA cm−2 and a TOF of 705 h−1 at −0.77 V versus RHE in 0.5 M KHCO3 than that of CoTCPP/CNTs. Meanwhile, the performance of CoTOMePP/CNTs was superior to CoTOPP/CNTs in FE (CO) and stability. The methylated derivatives exhibited enhanced electrocatalytic CO2 reduction performance, for the methylation of the hydroxyl and carboxyl might increase the solubility and suppress the aggregation of metal-porphyrin, helping Co-porphyrins disperse on the carbon nanotubes better.

Heteropoly acids as nontoxic, dual Lewis–Brønsted acids with high thermal stability can develop acid-catalyzed reactions. Combining these catalysts with other materials is of great interest to enhance their efficiency and capability. Despite all the outstanding properties of heteropoly acids, their solubility in water and most organic solvents limits their application. So, in presented research, immobilization of phosphomolybdic acid (PMA) on prepared N-doped graphene oxide (NGO/PMA) was done to synthesize a solid acid, green and effective catalyst for the multicomponent synthesis of three kinds of spirooxindole structures. The preparation of new NGO-based solid acid catalyst was performed through a three-step method and identified by FTIR, TEM, mapping elemental analysis, SEM, EDX, and XRD techniques. Reusability of the catalyst, short reaction times (1:20–2 h), green condition, and easy workup as well as high yield of products (90–95%) are some merits of this research.

Ultraviolet (UV) radiation is harmful to the skin. Therefore, it capitalized on the properties of thiophene and pyridine derivatives to prepare new textile-protective agents with improved UV protection factor (UPF) factor. This embodies the preparation and characterization of “2-((3-cyano-4-(4-methoxyphenyl)-6-(thiophene-2-yl)pyridine-2-yl)oxy)acetohydrazide” (HZ) in complex with Ni(II), Cu(II), Zn(II), or Cd(II), using proton nuclear magnetic resonance (1H NMR), carbon-13 nuclear magnetic resonance (13C NMR), X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), and thermal analysis techniques. Characterization of cotton fabric-based cellulose (CELL) in complex with the synthesized agents using FTIR spectroscopy, X-ray spectroscopy, and scanning electron microscopy–energy dispersive X-ray analysis (SEM–EDX) revealed deposition of the hydrazide and its metal complexes on the cellulosic fiber. Interestingly, cellulose complexation with Cu(II) was observed to have the highest value of the UPF. Computation of the reactivity indices using density functional theory (DFT) supports this finding, where the electrophilicity parameter of the modified fabric was found to correlate with the UPF wherein Cu(II) shows the highest value. The synthesized complexes could, therefore, provide lead structures for developing new UV-protective agents with enhanced coating characteristics.

A one-pot and efficient catalytic protocol has been developed to synthesize pharmaceutically critical 2-substituted benzimidazoles and benzothiazoles using magnetite dopamine-supported copper nanoparticles (Fe3O4@PDA/CuCl2) as a heterogeneous catalyst. This selective transformation proceeds via oxidative cross-coupling of readily available benzylic amines with o-phenylenediamine/2-aminothiophenol. This one-pot green method proceeds smoothly, under mild conditions, avoids the usage of toxic metals, tolerates a variety of functionalities, and is amenable to gram scale. Furthermore, this easy-to-prepare magnetic nanocatalyst can be separated by magnetic decantation after the reaction, thereby making it more sustainable.

The measurement of Cd (II) ions in various matrices requires the development of sensors that are selective, sensitive, and simple to produce. The cadmium complex of a ligand prepared by the reaction of 2-pyridinecarbohydrazide with sodium 3-formyl-4-hydroxybenzenesulfonate, [Cd (NaPH)(H2O)].H2O, was synthesized, analyzed by elemental analysis, and structurally elucidated using various spectroscopic techniques. The infrared spectrum of Cd (II) complex suggests a bi-negative tri-dentate ONO behavior for the ligand via deprotonated form of both the enolic oxygen atom (C-O−) and the hydroxyl group of phenolic ring in addition to the azomethine group. The thermal behavior of this complex was revealed using TGA analysis. Applying Coast–Redfern and Horowitz–Metzger equations, we were able to calculate the kinetic and thermodynamic parameters to support the proposed fragmentation experiment for the Cd (II) complex. Cyclic voltammetry measurement was measured to estimate the electrochemical behavior of the Cd (II) ions as well as the impact of adding various NaH2PH ligand concentrations. The biological applications of [Cd (NaPH)(H2O)].H2O complex were assessed as antioxidant, anticancer, and antimicrobial. Based on the Cd (II) complex, we were able to modify Cd (II) ions carbon paste electrode (modified carbon paste electrode, MCPE) as a Cd (II) selective modifier. The created electrode displays a Nernstian slope in the linear range of 0.0001 to 10 mmol/L of 29.16 ± 0.03 mV decade−1, a quick reaction time of 6 s, and pH independence from 3–7. The suggested MCPE demonstrated strong selectivity to Cd (II) ions relative to many other cations and displayed negligible change in the slope or operating range if the experiment was achieved in a partially non-aqueous solution. This fabricated MCPE was used to determine Cd (II) ions in diverse water samples.

Fluoroquinolones emerged as one of potent therapeutic agents, targeting DNA-signalling pathways. Thus, efforts were spent to create novel quinolones for optimizing their antimicrobial and anticancer properties. Therefore, the new compound N,N′-phenylene (bis1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-1,4-dihydroquinoline-3-carboxylic acid) (H2Enro-o-phdn) in addition to its related chelates-contained metals were synthesised and described by spectroscopic, physical methods and thermal analyses. The reaction between H2Enro-o-phdn and trivalent La(III), Y(III), and Fe(III) and tetravalent Zr(IV) chloride with molar ratio 1:1 (M:H2Enro-o-phdn) yielded the production of chelates. The infrared results elucidate the binding mode of H2Enro-o-phdn by means of azomethine nitrogen and carboxylato oxygen atoms as tetradentate. The thermal analyses assured the proposed formula as well as existence of coordinated and latticed H2O molecules. Kinetic parameters for investigated metal complexes were quantified utilisation Horowitz–Metzger in addition to Coats–Redfern methods. Regarding antibacterial efficacy, Y(III) and Fe(III) complexes showed a robust inhibitory activity towards negative-gram stained (Escherichia coli and Salmonella typhi) and positive-Gram stained (Staphylococcus aureus and “spore-forming” Bacillus cereus) strains. Then, we further tested the cytotoxicity of the complexes against the survival of colon-cancer cells line (CT26). In this regard, in the descending order, Fe(III) > Zr(IV) > La(III) complexes possessed a powerful antitumour activity with IC50 values 6.38, 5.36, and 4.03 μM, respectively, compared with the anticancer drug-reference cisplatin (16.77 μM). To understand the precise mechanism behind the tumour cell death, Western-blotting analysis was conducted, to monitor the changes in levels of pro-apoptotic “P53” protein after drug-treatment. Results indicated that H2Enro-o-phdn with higher covalency metals, like La(III) and Zr(IV) complexes, had the highest upregulation of P53 expression in a threefold to fourfold compared cisplatin, paving the way for a novel P53-based colon-cancer therapies.