发育蛋白 Hedgehog、Notch 和 Wn t是调控多种组织中细胞命运、增殖、迁移和分化的关键因子。它们相关的信号通路在肿瘤中经常被激活，特别是在罕见的癌症干细胞亚群中。
Wnt 信号通路是动物体内一条保守的通路。Wnt 信号通路失调会对胚胎发育产生严重后果，现在人们已经充分认识到 Wnt 信号通路缺陷是导致包括癌症在内的许多人类疾病的原因之一。Hedgehog 信号通路与肿瘤发生有关，在多种癌症中异常激活。Notch 信号通路在动物中高度保守。它在细胞间通讯中起重要作用，并进一步调控胚胎发育。
Chem960 可以提供 Wnt/Hedgehog/Notch 信号通路相关小分子抑制剂化合物，是研究干细胞及筛选抗肿瘤药物的有用工具。
• A unique collection of 245 small molecule inhibitors with biological activity used for Wnt/Hedgehog/Notch pathway research and screening.
• Targets include Notch, Gli, GSK-3, Hedgehog, Porcupine, sFRP-1, Smo, Wnt, β-catenin, etc.
• A useful tool for the research of Wnt/Hedgehog/Notch-related regulation and diseases.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
