转化生长因子β (Transforming growth factor beta，TGF-β) 信号通路在成体组织及胚胎发育中参与了多种细胞过程的调控，包括细胞生长、细胞分化、细胞凋亡、细胞内稳态及其他细胞功能。TGF-β 超家族包括 TGF-βs，骨形成蛋白 (BMPs)，activins 及相关蛋白。TGF-β 信号通路起始于 TGF-β 超家族配体与TGF-β II 型受体结合，TGF-β II 型受体是一种丝氨酸/苏氨酸激酶受体，能够进一步激活 TGF-β I 型受体，激活的 TGF-β I 型受体可以进一步磷酸化受体调控的SMADs蛋白 (R-SMADs)，磷酸化的 R-SMADs 可以与 coSMAD (如SMAD4) 结合，R-SMAD/coSMAD 复合物在细胞核内聚集，作为转录因子参与调控靶基因的表达。TGF-β 信号通路失调会导致一些发育缺陷及疾病的发生，如癌症，某些骨骼疾病，慢性肾脏疾病等。
Chem960 收集TGF-β/SMAD 信号相关小分子抑制剂化合物，是 TGF-β/SMAD 信号通路相关药物筛选和疾病研究的有用工具。
• A unique collection of 288 TGF-beta/Smad inhibitors for high throughput screening (HTS) and high content screening (HCS).
• Targets include PKC, ROCK, TGF-beta/Smad, and TGF-β Receptor.
• A useful tool for researching TGF-beta/Smad-related regulation and diseases.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
