成体干细胞具有自我更新和无限分化的潜能，对组织的稳态和再生具有重要作用。干细胞自我更新潜能主要体现在干细胞多次或无限分化能力上。一些信号通路如 Notch，Wnt，Hedgehog 信号通路及Polycomb 蛋白家族参与了干细胞的自我更新过程。近年来的研究主要集中在肿瘤干细胞 (CSCs)、诱导多能干细胞 (iPSCs)、神经干细胞和胚胎干细胞多能性的维持等方面。其中，肿瘤干细胞被认为是肿瘤发生、生长和复发的原因，对癌症治疗具有重要意义。
Chem960 收录了相关小分子抑制剂化合物，可以用于干细胞调控及信号通路研究。
• A unique collection of 434 small molecule inhibitors with biological activity used for stem cell regulatory and signaling pathway research.
• Targets such as GSK-3, Hedgehog, Notch, JAK, ROCK, Wnt, γ-secretase, Casein Kinase, etc.
• A powerful tool for researching the mechanism behind stem cells, regenerative therapy, drug screening based on tumor stem cells, as well as other pharmaceutical and biological applications.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some protein kinase inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and customer reviews.
• NMR and HPLC validated to ensure the highest purity.
• All compounds are in stock and continuously updated.
