转录是 DNA 中遗传信息转化为蛋白质的第一步，也是调控基因表达的重要环节。蛋白编码基因的转录是由 RNA 聚合酶 II 和被称为转录因子 (TFs) 的一系列辅助蛋白完成。转录因子在细胞生长、分化和对环境信号的响应的长期调控中发挥重要的作用。转录因子调节失调与多种疾病发生有关，如糖尿病，炎症相关疾病及癌症等。因此这些转录因子作为药物靶点具有较高疾病治疗价值。
Chem960 收录了靶向转录因子的小分子抑制剂化合物，Chem960 转录因子化合物库是研究转录因子作为治疗靶点及转录因子在疾病调控中的作用机制的有用工具。
• A unique collection of 242 small molecule compounds with validated transcription factor targets modulating properties.
• Targeting more than 60 transcription factors, such as AP-1, ATF6, BCL6, NF-κB, etc.
• A useful tool for the research of transcription factor-related regulation and diseases.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Detailed compound information with structure, IC50, and brief introduction.
• Validated NMR and HPLC to ensure high purity and quality.
• All compounds are in stock and continuously updated.
