大部分分子主要通过膜转运蛋白进出细胞，膜转运蛋白在细胞代谢、离子稳态、信号转导、免疫系统识别过程、能量转导等多种细胞功能中发挥重要作用。主要有三种转运蛋白，ATP 驱动的泵，通道蛋白和转运蛋白。离子通道和转运蛋白在维持细胞内稳态中发挥重要作用，这些转运蛋白基因的突变已在许多遗传疾病的发病机制中被发现。在中枢神经系统中，离子通道与许多疾病有关，如共济失调、麻痹、癫痫和耳聋等，但不限于此，这表明离子通道在启动和协调运动、感觉知觉以及信息编码和处理方面的作用。离子通道是药物开发中的一类主要靶点。
Chem960 收录的小分子调节剂可用于离子通道和膜转运体的研究，或相关药物的高通量筛选。
• A unique collection of 420 small molecule modulators used for Ion Channel and Membrane Transporter research.
• The library contains compounds targeting Membrane Transporters including Pgp, CRM1, BCRP, etc., and Ion Channels including CFTR, proton pump, sodium pump, calcium pump, etc.
• A useful tool for the research of drug absorption and distribution.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and summary.
• NMR and HPLC validated to ensure high purity.
• All compounds are in stock and continuously updated.
