MAPK 家族在复杂的细胞增殖、分化、发育、转化、凋亡等过程中发挥重要作用。在哺乳动物细胞中，发现有四种类型的 MAPK 级联通路，ERK1/2 信号通路，JNK 信号通路，p38 激酶信号通路和 ERK5 信号通路，他们会对不同的信号产生反应。MAPK 通路包含一组三级磷酸化依赖的激酶，包括 MAPK 激酶激酶 (MKKK) 、MAPK 激酶 (MKK) 和 MAPK。MAPK 信号通路参与多种疾病的发生，如阿尔茨海默病 (AD)，帕金森病 (PD)，肌萎缩性脊髓侧索硬化症 (ALS) 和各种癌症。
Chem960 收集关于 MAP K信号相关抑制剂的小分子抑制剂化合物，是 MAPK 相关的药物筛选和疾病研究的有用工具。
• A unique collection of 438 MAPK signaling inhibitors for high throughput screening (HTS) and high content screening (HCS).
• Targets such as ERK, JNK, MEK, p38 MAPK, Raf, RSK, etc.
• A useful tool for MAPK-related drug discovery and disease research.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
