细胞骨架参与细胞收缩、迁移、细胞器及小泡的运动、胞质分裂、细胞内信号转导，以及其他多种对细胞内环境稳定和生存至关重要的功能。它通过三种基本结构完成这些功能：F-肌动蛋白（F-actin）、微管（microtubules）和中间丝（intermediate filaments ，IFs）。细胞骨架是一种动态结构，其中三种主要的微丝和微管在多种蛋白质的影响下，调节其长度，聚合状态和交联水平。由于细胞骨架几乎参与了所有的细胞活动，细胞骨架蛋白畸变是许多疾病发生的根本原因，包括几种心血管疾病、神经退行性疾病、癌症、肝硬化、肺纤维化和水泡性皮肤病。
Chem960 收录了细胞骨架相关化合物，主要靶向细胞骨架信号通路中主要靶点，可以用于细胞骨架信号通路及相关疾病的研究。
• A unique collection of 1081 small molecules used for cytoskeleton research.
• Targets such as Kinesin, Microtubule/Tubulin, Arp2/3 Complex, Bcr-Abl, etc.
• Bioactivity and safety confirmed by preclinical research and clinical trials, some compounds have been approved by FDA.
• A useful tool to study cytoskeletal protein aberrations involved diseases such as cardiovascular disease, neurodegeneration, cancer, liver cirrhosis, etc.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and other chemical & biological data.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
