线粒体在细胞的许多重要进程中发挥关键作用，包括能量产生、脂肪酸氧化、三羧酸 (TCA) 循环、钙信号传导、通透性改变、凋亡和热产生等。越来越多的研究表明，许多疾病的发生都与线粒体功能受损有关，如 ROS（活性氧）积累增加，氧化磷酸化及 ATP 产生减少。目前，线粒体被认为是癌症、心血管疾病、神经相关疾病新药设计的重要靶点之一。一些小分子药物或生物制剂可以通过多种途径作用于线粒体，包括抑制电子传递链、氧化磷酸化解偶联、线粒体 Ca2+ 调节以及通过减少或增加线粒体 ROS 积累来控制氧化应激等。
Chem960 收录了线粒体靶向化合物，主要靶点涉及线粒体代谢、ATP合酶（ATP合酶）、线粒体自噬（Mitophagy）、活性氧（ROS）等。Chem960线粒体靶向库是进行线粒体相关药物开发及相关研究的重要工具。
• A unique collection of 195 mitochondria-targeted compounds for high throughput screening (HTS) and high content screening (HCS).
• Targets such as Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc.
• A useful tool for drug discovery of mitochondria-related diseases.
• Bioactivity and safety confirmed by preclinical research and /or clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and brief introduction.
• High purity and quality validated by NMR and LC/MS.
• All compounds are in stock and continuously updated.
