机械感受器能将外界的不同刺激转换成电信号，使我们能快速对环境做出反应。机械感受器分布在全身各处，包括皮肤、肌腱、肌肉、关节囊和内脏。在机械感受器中除了诺贝尔奖中提到的TRP和Piezo两种研究较多的通道以外，还有 KCNK、ENaC、ASIC2 等靶点，它们在生命体感知环境 、维持体内平衡等方面起到重要作用。
Chem960将提供与机械感受器相关的化合物，靶向不同机械感受器，如 TRP、Piezo、KCNK、ENaC等，Chem960机械感受器库是研究机械感受器和生命体感知的有力工具。
• A unique collection of 67 small molecule compounds targeted different kinds of mechanoreceptors.
• Targeting the key targets associated with mechanoreceptors, such as TRP, Piezo, KCNK, ENaC, etc.
• A useful tool for the research of mechanoreceptors and life perception.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Detailed compound information with structure, IC50, and brief introduction.
• High purity and quality validated by NMR and LC/MS.
• All compounds are in stock and continuously updated.
