12-Oxocalanolide A (Synonyms: (±)-12-Oxocalanolide A)

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12-Oxocalanolide A (compound 6) 是一种有效的人类免疫缺陷病毒 1 型 (HIV-1) 逆转录酶抑制剂，具有 IC₅₀ 和 EC< sub>50 分别为 2.8 和 12 μM。12-Oxocalanolide A 是 Calanolide 的类似物。

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12-Oxocalanolide A Chemical Structure

CAS No. : 161753-49-7

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生物活性
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参考文献

生物活性

12-Oxocalanolide A (compound 6) is a potent inhibitor of reverse transcriptase from human immunodeficiency virus type 1 (HIV-1) with an IC₅₀ and EC₅₀ of 2.8 and 12 μM, respectively. 12-Oxocalanolide A is the analogue of Calanolide^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
AA5	EC₅₀	2.8 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell	[PMID: 9873509]
B-cell	EC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in AA5 EBV-infected B-cell	[PMID: 9873509]
CCRF-CEM	EC₅₀	0.27 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain SK1 in CEM-SS T-cells Compound was evaluated for the anti-HIV activity against HIV strain SK1 in CEM-SS T-cells	[PMID: 9873509]
CCRF-CEM	EC₅₀	0.62 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain SK1 in CEM-SS T-cells Compound was evaluated for the anti-HIV activity against HIV strain SK1 in CEM-SS T-cells	[PMID: 9873509]
CCRF-CEM	EC₅₀	1.09 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS T-cells	[PMID: 9873509]
CCRF-CEM	EC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion	[PMID: 9873509]
CCRF-CEM	EC₅₀	> 10 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion Compound was evaluated for the anti-HIV activity against HIV strain IIIB in 174 x CEM T-cell:B-cell fusion	[PMID: 9873509]
CEM-SS	EC₅₀	0.15 μM Compound: 10	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	EC₅₀	0.17 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	0.17 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	0.27 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	0.4 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	0.51 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	0.52 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50 Compound was evaluated for the anti-HIV activity against HIV strain IIIB in CEM-SS Value was expressed as EC50	[PMID: 9873509]
CEM-SS	EC₅₀	0.9 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	1 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	1.2 μM Compound: (+/-)5	Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined Concentration required to protect CEM-SS cells from HIV-1 mediated cytopathicity by 50% relative to drug-free controls was determined	[PMID: 9083491]
CEM-SS	EC₅₀	1.24 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	1.66 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	1.88 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	3.41 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells	[PMID: 9873509]
CEM-SS	EC₅₀	6.12 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	19 μM Compound: (+/-)5	Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls Antiviral activity against HIV-1 determined by concentration which resulted in cytotoxicity of 50% of CEM-SS cell population relative to drug-free controls	[PMID: 9083491]
CEM-SS	IC₅₀	5.6 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	5.8 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	6.3 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	6.6 μM Compound: (+/-)-2	Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	9.3 μM Compound: 10	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain IIIB in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain RF in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells Compound was evaluated for the antiviral activity against HIV-1 strain SK1 in CEM-SS cells	[PMID: 9873509]
CEM-SS	IC₅₀	> 10 μM Compound: (-)-2	Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells Compound was evaluated for the antiviral activity against SIV delta in CEM-SS cells	[PMID: 9873509]
MT2	EC₅₀	0.56 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in MT2 T-cells Compound was evaluated for the anti-HIV activity against HIV strain IIIB in MT2 T-cells	[PMID: 9873509]
MT2	EC₅₀	2.62 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in MT2 T-cells Compound was evaluated for the anti-HIV activity against HIV strain IIIB in MT2 T-cells	[PMID: 9873509]
U-937	EC₅₀	3 μM Compound: (+/-)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in U937 monocytic cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in U937 monocytic cell	[PMID: 9873509]
U-937	EC₅₀	> 10 μM Compound: (+)-2	Compound was evaluated for the anti-HIV activity against HIV strain IIIB in U937 monocytic cell Compound was evaluated for the anti-HIV activity against HIV strain IIIB in U937 monocytic cell	[PMID: 9873509]

分子量

368.42

Formula

C₂₂H₂₄O₅

CAS 号

161753-49-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Zembower DE, et al. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C). J Med Chem. 1997;40(6):1005-1017. [Content Brief]

12-Oxocalanolide A 相关分类

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12-Oxocalanolide A161753-49-7(±)-12-Oxocalanolide AHIVHuman immunodeficiency virusreverse transcriptaseHIV-1CalanolideInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

12-Oxocalanolide A (Synonyms: (±)-12-Oxocalanolide A)

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12-Oxocalanolide A (Synonyms: (±)-12-Oxocalanolide A)

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