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  6. 13′-Hydroxy-δ-tocopherol

13′-Hydroxy-δ-tocopherol 是一种长链维生素 E 的代谢物。13′-Hydroxy-δ-tocopherol 可诱导细胞凋亡 (apoptosis)，并可轻微降低线粒体膜电位。13′-Hydroxy-δ-tocopherol 可用于肝细胞癌的研究。

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13′-Hydroxy-δ-tocopherol

13′-Hydroxy-δ-tocopherol Chemical Structure

CAS No. : 1308347-24-1

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13′-Hydroxy-δ-tocopherol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E. 13′-Hydroxy-δ-tocopherol can induces cells apoptosis and minor reduction in mitochondrial membrane potential. 13′-Hydroxy-δ-tocopherol can be used for the research of hepatocellular carcinoma[1].

体外研究
(In Vitro)

13′-Hydroxy-δ-tocopherol (Compound δ-13′-OH) ( 24 h) 在 HepG2 细胞中表现出较弱的抗增殖活性，其 EC50 大于 50 μM[1]。
13′-Hydroxy-δ-tocopherol (20 μM; 6 h) 在 HepG2 细胞中诱导显著的凋亡性细胞死亡，诱导 caspase-3、caspase-7、caspase-9 和 PARP-1 的剪切[1]。
13′-Hydroxy-δ-tocopherol (10 μM; 6 h) 在 HepG2 细胞中不会显著诱导细胞内或线粒体内 ROS 的生成[1]。
13′-Hydroxy-δ-tocopherol (20 μM; 1 h) 在 HepG2 细胞中可使线粒体膜电位显著降低 20%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

13′-Hydroxy-δ-tocopherol 相关抗体:

Western Blot Analysis[1]

Cell Line: human hepatoma HepG2 cells
Concentration: 20 μM
Incubation Time: 6 h
Result: Induced less pronounced activation of caspase-3, caspase-7, and caspase-9, as well as PARP-1 cleavage, compared to long-chain carboxychromanol metabolites.
分子量

418.65

Formula

C27H46O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

13′-Hydroxy-δ-tocopherol 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

13′-Hydroxy-δ-tocopherol1308347-24-1intrinsic apoptotic pathwayhepatocellular carcinomaHepG2 cellsmitochondrial membrane potentialliver-derived cancer cellscaspase-3caspase-7apoptotic cell deathreactive oxygen speciescaspase-9Inhibitorinhibitorinhibit

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