2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. 2α-Ferrocenylmethyl-DHT

2α-Ferrocenylmethyl-DHT 是一种双氢睾酮衍生的二茂铁 - 甾体结合物。2α-Ferrocenylmethyl-DHT 抑制多种癌细胞的生长。2α-Ferrocenylmethyl-DHT 可诱导卵巢癌细胞发生 S 期细胞周期阻滞，升高细胞内的铁水平，诱导依赖 ROS 的细胞死亡，破坏卵巢癌细胞多细胞肿瘤球的完整性。2α-Ferrocenylmethyl-DHT 可用于前列腺癌、卵巢癌的研究。

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2α-Ferrocenylmethyl-DHT

2α-Ferrocenylmethyl-DHT Chemical Structure

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2α-Ferrocenylmethyl-DHT 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2α-Ferrocenylmethyl-DHT is a dihydrotestosterone-derived ferrocene-steroid conjugate. 2α-Ferrocenylmethyl-DHT inhibits the growth of various cancer cells. 2α-Ferrocenylmethyl-DHT induces S-phase cell cycle arrest in ovarian cancer cells, elevates intracellular iron levels, triggers ROS-dependent cell death, and disrupts the integrity of multicellular tumor spheroids of ovarian cancer cells. 2α-Ferrocenylmethyl-DHT can be used in the research of prostate cancer and ovarian cancer[1].

体外研究
(In Vitro)

2α-Ferrocenylmethyl-DHT (Compound 2) (3.12-50 μM; 72 h) 可强效抑制 OVCAR-3 (IC50 = 2.8 μM)、PC-3 (IC50 = 16.8 μM)、LNCaP (IC50 = 16 μM) 癌细胞以及非恶性 MRC-5 成纤维细胞 (IC50 = 8.5 μM) 的生长，对 OVCAR-3 细胞具有中等肿瘤选择性[1]。
2α-Ferrocenylmethyl-DHT (2.8 μM; 48-72 h) 可在 OVCAR-3 细胞中诱导时间依赖性 S 期阻滞，且 Sub-G1 期细胞累积量极低[1]。
2α-Ferrocenylmethyl-DHT (50 μM; 24 h) 处理可使 OVCAR-3 细胞内的铁水平升高 21 倍[1]。
2α-Ferrocenylmethyl-DHT (0.3-30 μM; 72 h) 可在 OVCAR-3 细胞中诱导依赖 ROS、不依赖半胱天冬酶的细胞死亡[1]。
2α-Ferrocenylmethyl-DHT (3.12-50 μM; 72 h) 会破坏 OVCAR-3 多细胞肿瘤球的完整性并抑制其生长，IC50 为 14 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2α-Ferrocenylmethyl-DHT 相关抗体:

Cell Proliferation Assay[1]

Cell Line: human prostate adenocarcinoma PC-3 cells, LNCaP cells, ovarian adenocarcinoma OVCAR-3 cells, non-malignant MRC-5 fetal lung fibroblasts
Concentration: 3.12, 6.25, 12.5, 25, 50 μM
Incubation Time: 72 h
Result: Inhibited PC-3 cell growth with an IC50 of 16.8 μM.
Inhibited LNCaP cell growth with an IC50 of 16 μM.
Inhibited OVCAR-3 cell growth with an IC50 of 2.8 μM.
Inhibited MRC-5 cell growth with an IC50 of 8.5 μM.
Achieved a selectivity index of 3.03 for OVCAR-3 cells relative to MRC-5 cells.

Cell Cycle Analysis[1]

Cell Line: human ovarian adenocarcinoma OVCAR-3 cells
Concentration: 2.8 μM
Incubation Time: 48 h; 72 h
Result: Increased S-phase population to 24.1=% after 72 h, compared to 10=% in untreated controls.
Reduced G1 phase population and elevated G2/M phase population after 72 h.
Increased Sub-G1 fraction to 9.3% after 72 h.

Cell Proliferation Assay[1]

Cell Line: 3D multicellular tumor spheroids (MCTSs) of human ovarian adenocarcinoma OVCAR-3 cells
Concentration: 3.12, 6.25, 12.5, 25, 50 μM
Incubation Time: 72 h
Result: Inhibited OVCAR-3 MCTS growth with an IC50 of 14 μM.
Induced weakening of intercellular contacts and loss of spheroid compactness starting at 6.25 μM.
Caused complete loss of spheroid architecture at 50 μM.
分子量

472.48

Formula

C30H40FeO
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2α-Ferrocenylmethyl-DHT 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2α-Ferrocenylmethyl-DHTReactive Oxygen Species (ROS)ferrocene-steroid conjugateOVCAR-3 cellsPC-3cellsLNCaP cellsMRC-5cellsprostate cancerovarian cancerInhibitorinhibitorinhibit

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