2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 2'-Deoxy-N-methyl-AMP ammonium

2'-Deoxy-N-methyl-AMP ammonium 是一种 N6-取代腺嘌呤核苷酸衍生物，是一种糖基供体。一方面，2'-Deoxy-N-methyl-AMP ammonium 可作为 N6-methyl-AMP 氨基水解酶的特异性底物，被催化转化为 dIMP 从而参与核苷酸代谢循环。另一方面，2'-Deoxy-N-methyl-AMP ammonium 还能作为鸟苷二磷酸 (GDP) 连接的岩藻糖衍生物供体，在 α-1,3-岩藻糖基转移酶的介导下驱动蛋白质的位点特异性糖缀合反应。2'-Deoxy-N-methyl-AMP ammonium 是研究核苷酸修饰及蛋白质糖基化机制的重要分子工具。

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2'-Deoxy-N-methyl-AMP ammonium

2'-Deoxy-N-methyl-AMP ammonium Chemical Structure

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Other Forms of 2'-Deoxy-N-methyl-AMP ammonium:

2'-Deoxy-N-methyl-AMP ammonium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation[1][2].
体外研究
(In Vitro)

2'-Deoxy-N-methyl-AMP ammonium (37 °C) 可被纯化的大鼠肝脏 N6-甲基-AMP 氨基水解酶高效转化为 dIMP，其 Km 值为 0.9 ± 0.2 μmol/L，Vmax 值为 253.7 ± 10.1 nmol min-1 mg-1，Vmax/Km 比值为 281.9 × 103 L min-1 mg-1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Deoxy-N-methyl-AMP ammonium 相关抗体:
分子量

362.28

Formula

C11H19N6O6P
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

2'-Deoxy-N-methyl-AMP ammonium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxy-N-methyl-AMPNucleoside Antimetabolite/AnalogdIMPJIMT-1 cellsN6-substituted adenine nucleotideα-13-fucosyltransferaseN6-methyl-AMP aminohydrolasehuman serumrat livernucleotide derivativeSK-Br-3 cellsguanosine diphosphateInhibitorinhibitorinhibit

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