2. Immunology/Inflammation
  3. NO Synthase
  4. 2-Iminopiperidine (hydrochloride)

2-Iminopiperidine (compound 13) hydrochloride 是一种具有口服活性的诱导型一氧化氮合酶抑制剂。2-Iminopiperidine (hydrochloride) 可用于研究由 NO 介导的关节炎、炎症性肠病、糖尿病、异常性疼痛、脑缺血及其他中枢神经系统疾病。

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2-Iminopiperidine (hydrochloride)

2-Iminopiperidine (hydrochloride) Chemical Structure

CAS No. : 16011-96-4

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2-Iminopiperidine (hydrochloride) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Iminopiperidine (compound 13) hydrochloride is an orally active inducible nitric oxide synthase inhibitor. 2-Iminopiperidine (hydrochloride) can be used to investigate NO-mediated arthritis, inflammatory bowel disease, diabetes, allodynia, cerebral ischemia and other central nervous system diseases[1].

体外研究
(In Vitro)

2-Iminopiperidine (compound 13) hydrochloride (处理 15 分钟) 可在体外抑制小鼠诱导型一氧化氮合酶 (IC50 = 0.6 μM) 和大鼠脑组成型一氧化氮合酶 (IC50 = 2.0 μM)[1]。
2-Iminopiperidine (冰上预孵育 1 小时；37°C 孵育 1 小时) 可在体外抑制 LPS 诱导的 RAW 264.7 细胞的亚硝酸盐生成 (IC50 = 14 μM)in vitro[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2-Iminopiperidine (hydrochloride) 相关抗体:
体内研究
(In Vivo)

2-Iminopiperidine (compound 13) hydrochloride (1-100 mg/kg；口服给药) 可抑制大鼠体内 LPS 诱导的一氧化氮生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (systemic hypotension/toxic shock induced by intraperitoneal injection of 10 mg/kg LPS)[1]
Dosage: 1 mg/kg; 10 mg/kg; 100 mg/kg
Administration: p.o.
Result: Dose-dependently decreased the LPS-induced rise in plasma nitrites (a marker of nitric oxide production).
分子量

134.61

Formula

C5H11ClN2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Iminopiperidine (hydrochloride) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Iminopiperidine (hydrochloride)16011-96-4NO SynthaseNitric oxide synthasesNOSnitrite productionratsplasma nitritessystemic hypotensioninflammatory bowel diseaseconstitutive nitric oxide synthaseRAW 264.7 cellsseptic shockinducible nitric oxide synthaseLPSInhibitorinhibitorinhibit

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