2. Cell Cycle/DNA Damage Epigenetics Apoptosis Cytoskeleton
  3. PARP Apoptosis Microtubule/Tubulin
  4. 2'-Nitroflavone

2'-Nitroflavone 是一种 PARP1 抑制剂。2'-Nitroflavone 可抑制三阴性乳腺癌细胞增殖，诱导细胞周期阻滞和凋亡 (apoptosis)。2'-Nitroflavone 还可抑制三阴性乳腺癌细胞和内皮细胞的迁移。2'-Nitroflavone 具有抗肿瘤的活性，可用于三阴性乳腺癌等肿瘤的研究。

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2'-Nitroflavone

2'-Nitroflavone Chemical Structure

CAS No. : 53277-26-2

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2'-Nitroflavone 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2'-Nitroflavone is a PARP1 inhibitor. 2'-Nitroflavone inhibits the proliferation, induces cell cycle arrest and apoptosis of triple-negative breast cancer cells. 2'-Nitroflavone also inhibits the migration of triple-negative breast cancer cells and endothelial cells. 2'-Nitroflavone exhibits antitumor activity and can be used in the research of tumors such as triple-negative breast cancer[1].

IC50 & Target[1]

PARP1

 

体外研究
(In Vitro)

2'-Nitroflavone (1.25-40 μM；0-96 h) 可抑制 MDA-MB-231、BT-549 和 MDA-MB-468 三阴性乳腺癌 (TNBC) 细胞的活力，处理 72 h 时的 IC50 值分别为 4.0 μM、9.2 μM 和 6.5 μM，对 EA.hy926 内皮细胞 96 小时 IC50 为 14.5 μM[1]。
2'-Nitroflavone (0-25 μM；72-144 h) 可抑制三阴性乳腺癌细胞的克隆形成和迁移，诱导细胞周期阻滞和凋亡[1]。
2'-Nitroflavone (1-25 μM；72 h) 可降低 MDA-MB-231 和 BT-549 细胞中 α-tubulin 的蛋白水平，破坏细胞中 α-tubuli 的排列，并诱导多极有丝分裂纺锤体形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Nitroflavone 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 5 μM
Incubation Time: 72 h
Result: Induced S and G2/M arrest in MDA-MB-231 cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 1, 5, 25 μM
Incubation Time: 72 h
Result: Significantly decreased viable cells and increased the percentage of early apoptotic cells at 25 μM compared to vehicle.\nSignificantly increased the percentage of hypodiploid cells at 5 and 25 μM compared to vehicle.

Western Blot Analysis[1]

Cell Line: MDA-MB-231, BT-549
Concentration: 1, 5, 25 μM
Incubation Time: 72 h
Result: Significantly decreased α-tubulin protein expression in both cell lines at 25 μM.
Did not affect actin protein levels at any concentration tested.
体内研究
(In Vivo)

2'-Nitroflavone (20 mg/kg；腹腔注射；每周 5 次，连续 2 周) 在 4T1 三阴性乳腺癌小鼠模型中具有抗肿瘤的活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, 6-8 weeks old, 20-25 g, orthotopic syngeneic 4T1 cell model)[1]
Dosage: 20 mg/kg
Administration: i.p.; daily 5 times per week; 2 weeks
Result: Significantly decreased relative tumor volume compared to vehicle controls.
Had significant differences in body, liver, spleen, heart, or kidney weight between groups.
分子量

267.24

Formula

C15H9NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2'-Nitroflavone 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Nitroflavone53277-26-2PARPApoptosisMicrotubule/Tubulinpoly ADP ribose polymerase triple-negative breast cancer modelMDA-MB-231PARP1BT-549endothelial cellstubulinMDA-MB-468Inhibitorinhibitorinhibit

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