2. Metabolic Enzyme/Protease
  3. FXR
  4. 2-Oxokolavenol

2-Oxokolavenol 是一种靶向法尼醇 X 受体 (FXR) 的选择性激动剂，EC50 约为 3.7 μM。2-Oxokolavenol 通过结合 FXR 配体结合口袋、招募共激活因子并诱导 FXR 转录活性，以 FXR 依赖方式发挥抗对乙酰氨基酚 (HY-66005) 诱导肝细胞损伤的活性。2-Oxokolavenol 能够从 Aglaia spectabilis (楝科米仔兰属植物壮丽米仔兰) 中天然提取得到，可用于肝脏疾病相关研究。

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2-Oxokolavenol

2-Oxokolavenol Chemical Structure

CAS No. : 130395-82-3

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2-Oxokolavenol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2-Oxokolavenol is a selective agonist targeting the farnesoid X receptor (FXR), with an EC50 of ~3.7 μM. 2-Oxokolavenol exerts its activity against Acetaminophen (HY-66005)-induced hepatocyte damage in an FXR-dependent manner by binding to the FXR ligand-binding pocket, recruiting co-activators, and inducing FXR transcriptional activity. 2-Oxokolavenol can be naturally extracted from Aglaia spectabilis (a plant of the Aglaia genus in the Meliaceae family) and can be used in research related to liver diseases[1].

分子量

304.47

Formula

C20H32O2
CAS 号
中文名称

‌2-氧代克拉维醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2-Oxokolavenol 相关分类

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Keywords:

2-Oxokolavenol130395-82-3‌2-氧代克拉维醇FXRNR1H4Inhibitorinhibitorinhibit

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