2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 20-HETE IN-3

20-HETE IN-3 是一种具有口服生物利用度的 20-HETE 生成抑制剂。20-HETE IN-3 可用于肥胖症的研究。

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20-HETE IN-3

20-HETE IN-3 Chemical Structure

CAS No. : 3119850-82-4

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20-HETE IN-3 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

20-HETE IN-3 is an orally bioavailable 20-HETE synthesis inhibitor. 20-HETE IN-3 can be used in the research of obesity[1].

体外研究
(In Vitro)

20-HETE IN-3 (example 1) (0-2 μM, HLM; 0-10 μM, RLM; 20 min) 可强效抑制人肝微粒体和大鼠肝微粒体中 20-HETE 的生成，其在人肝微粒体中的 IC50 为 32.24 nM，在大鼠肝微粒体中的 IC50 为 20.12 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

20-HETE IN-3 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax AUC0-24 T1/2
Mice[1] 10 mg/kg p.o. 3224 ng/mL 40316 ng·h/mL 4.94 h
体内研究
(In Vivo)

20-HETE IN-3 (example 1) (10 mg/kg, 10 mL/kg; po; 单次) 灌胃给药小鼠后，展现出较高的血药浓度峰值 (Cmax 为 3224 ng/mL) 与体内暴露量 (AUC0-24 h 为 40316 ng·h/mL)，且消除半衰期为 4.94 h[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

374.48

Formula

C23H26N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

20-HETE IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

20-HETE IN-33119850-82-4Cytochrome P450CYPs肥胖症20-HETE formationrat liver microsomeshuman liver microsomesInhibitorinhibitorinhibit

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目录号：
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