2. Anti-infection
  3. EBV
  4. 21-Hydroxyisoohchininolide

21-Hydroxyisoohchininolide 是一种 salannin 类柠檬苦素。21-Hydroxyisoohchininolide 可抑制 LPS (HY-D1056) 诱导的小鼠巨噬细胞一氧化氮生成。21-Hydroxyisoohchininolide 对白血病细胞和乳腺癌细胞具有细胞毒活性。21-Hydroxyisoohchininolide 可抑制 Phorbol 12-myristate 13-acetate (TPA) (HY-18739) 诱导的淋巴细胞中 Epstein-Barr 病毒早期抗原激活。21-Hydroxyisoohchininolide 可用于白血病、乳腺癌及感染性疾病的研究。

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21-Hydroxyisoohchininolide

21-Hydroxyisoohchininolide Chemical Structure

CAS No. : 1429747-14-7

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21-Hydroxyisoohchininolide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

21-Hydroxyisoohchininolide is a salannin-type limonoid. 21-Hydroxyisoohchininolide inhibits lipopolysaccharide (LPS, HY-D1056)-induced nitric oxide production in mouse macrophages. 21-Hydroxyisoohchininolide exhibits cytotoxic activity against leukemia cells and breast cancer cells. 21-Hydroxyisoohchininolide suppresses phorbol 12-myristate 13-acetate (PMA) (HY-18739)-induced activation of Epstein-Barr virus early antigen in lymphocytes. 21-Hydroxyisoohchininolide can be used for the research of leukemia, breast cancer and inflammatory diseases[1].

体外研究
(In Vitro)

21-Hydroxyisoohchininolide (1-100 μM; 48 h) 对 HL60 人白血病细胞 (IC50 = 22.7 μM) 和 SK-BR-3 人乳腺癌细胞 (IC50 = 91.5 μM) 表现出细胞毒性，但在处理 48 h 后对 A549 人肺癌细胞和 AZ521 人胃癌细胞无细胞毒性[1]。
21-Hydroxyisoohchininolide (1-100 μM; 18 h) 可抑制 LPS 诱导的 RAW 264.7 小鼠巨噬细胞一氧化氮生成，其 IC50 为 87.3 μM，且在与 LPS 共孵育 16 h 后对细胞无细胞毒性[1]。
21-Hydroxyisoohchininolide 可抑制 TPA 诱导的 Raji 细胞中 EBV-EA 的激活，其 IC50 为相对于 32 pmol TPA 的 493 摩尔比；在最高测试摩尔比 1000:1 时，细胞存活率为 60%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

21-Hydroxyisoohchininolide 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HL60 human leukemia cells, AZ521 human stomach cancer cells, A549 human lung cancer cells, SK-BR-3 human breast cancer cells
Concentration: 1, 10 and 100 μM
Incubation Time: 48 h
Result: Exhibited cytotoxicity against HL60 cells with an IC50 of 22.7 μM.
Exhibited cytotoxicity against SK-BR-3 cells with an IC50 of 91.5 μM.
Showed no cytotoxicity (IC50 > 100 μM) against A549 and AZ521 cells.
分子量

634.71

Formula

C36H42O10
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

21-Hydroxyisoohchininolide 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

21-Hydroxyisoohchininolide1429747-14-7EBVEpstein-Barr VirusHL60 human leukemia cellsEpstein-Barr virus early antigenmouse macrophagesMelia azedarach L.breast cancer cellsleukemia cellsRaji cellslymphocytesSK-BR-3 human breast cancer cellsRAW 264.7 murine macrophage cellsInhibitorinhibitorinhibit

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