1. Others Metabolic Enzyme/Protease
  2. Drug Isomer Thrombin
  3. (21S)-Argatroban

(21S)-Argatroban 是 Argatroban (HY-B0375) 的一种异构体,是一种 thrombin 抑制剂。(21S)-Argatroban 可延长凝血时间,减少血小板黏附与聚集。

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(21S)-Argatroban

(21S)-Argatroban Chemical Structure

CAS No. : 121785-72-6

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Other Forms of (21S)-Argatroban:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(21S)-Argatroban is an isomer of Argatroban (HY-B0375) and is a thrombin inhibitor. (21S)-Argatroban can prolong blood clotting time, reduces platelet adhesion and aggregation[1].

体内研究
(In Vivo)

(21S)-Argatroban (0.4 mg/kg, intravenous infusion, once daily for 3 consecutive days) significantly prolongs whole blood clotting time, recalcification time, prothrombin time, thrombin time and activated partial thromboplastin time and reduces platelet adhesion, aggregation in normal domestic dogs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Domestic dogs[1]
Dosage: 0.4 mg/kg
Administration: intravenous infusion, once daily for 3 consecutive days
Result: Increased CT time from 390.8-551.8.
Increased RT time from 143.2-196.5.
Increased PT time from 5.6-9.6.
Increased TT time from 11.1-53.3.
Increased ATPP time from 20-24.5.
分子量

508.64

Formula

C23H36N6O5S

CAS 号
中文名称

21S-阿加曲班

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
(21S)-Argatroban
目录号:
HY-116363A
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