2. Immunology/Inflammation Anti-infection
  3. NO Synthase EBV
  4. 23-Hydroxyohchininolide

23-Hydroxyohchininolide 是一种被发现存在于 Melia azedarach L. 叶片中的柠檬苦素类化合物。23-Hydroxyohchininolide 可抑制 LPS (HY-D1056) 诱导的 NO 生成，并对人白血病细胞和胃癌细胞发挥细胞毒活性。23-Hydroxyohchininolide 可抑制 TPA (HY-18739) 诱导的 Epstein-Barr 病毒早期抗原激活。23-Hydroxyohchininolide 可用于癌症、感染及炎症性疾病的相关研究。

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23-Hydroxyohchininolide

23-Hydroxyohchininolide Chemical Structure

CAS No. : 1429747-10-3

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23-Hydroxyohchininolide 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease[1].

体外研究
(In Vitro)

23-Hydroxyohchininolide (Compound 8) (48 h) 对 HL60 白血病细胞 (IC50 = 25.1 ± 3.2 μM) 和 AZ521 胃癌细胞 (IC50 = 78.5 ± 2.9 μM) 表现出细胞毒活性，但对 A549 肺癌细胞或 SK-BR-3 乳腺癌细胞无活性 (IC50 >100μM)[1]。
23-Hydroxyohchininolide (2 h pre-incubation, then 16 h with LPS) 可抑制 LPS (HY-D1056) 诱导的 RAW 264.7 巨噬细胞 NO 生成，其 IC50 为 58.6 ± 1.9 μM；且在最高 100 μM 的浓度下，对该细胞无细胞毒性[1]。
23-Hydroxyohchininolide 可抑制 Raji 细胞中 TPA (HY-18739) 诱导的 EBV-EA 激活，其相对于 32 pmol TPA 的 IC50 为 497 的摩尔比[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

23-Hydroxyohchininolide 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HL60 (leukemia), AZ521 (stomach), A549 (lung), SK-BR-3 (breast) human cancer cell lines
Concentration: 1×10-6 to 1×10-4 g/mL
Incubation Time: 48 h
Result: Exhibited cytotoxicity against HL60 cells with an IC50 of 25.1 ± 3.2 μM.
Exhibited cytotoxicity against AZ521 cells with an IC50 of 78.5 ± 2.9 μM.
Showed no cytotoxicity (IC50 > 100 μM) against A549 and SK-BR-3 cells.
分子量

634.71

Formula

C36H42O10
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

23-Hydroxyohchininolide 相关分类

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Keywords:

23-Hydroxyohchininolide1429747-10-3NO SynthaseEBVNitric oxide synthasesNOSEpstein-Barr Virushuman leukemia cellsHL60 leukemia cellshuman stomach cancer cellsEpstein-Barr virus early antigenmouse macrophagesMelia azedarach L.B lymphocyteslipopolysaccharide12-O-tetradecanoylphorbol-13-acetateAZ521 stomach cancer cellsInhibitorinhibitorinhibit

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