2. Apoptosis
  3. Apoptosis
  4. 2DG-ODDA

2DG-ODDA 是一种具有强效抗肿瘤活性的 2- 脱氧葡萄糖 (2-DG) (HY-13966) 衍生物。2DG-ODDA 可诱导细胞凋亡 (apoptosis) 并降低 ATP 生成。2DG-ODDA 可通过脂肪酸和葡萄糖转运蛋白摄取，并被 α-Mannosidase (HY-P2950) 裂解，释放出 2DG，从而抑制 N- 糖基化并干扰细胞代谢。2DG-ODDA 可抑制 4T1 小鼠模型中的肿瘤生长。2DG-ODDA 可用于三阴性乳腺癌 (TNBC) 的研究。

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2DG-ODDA

2DG-ODDA Chemical Structure

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2DG-ODDA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC)[1].

体外研究
(In Vitro)

2DG-ODDA (80 μM；24 小时) 可显著降低 4T1 TNBC 细胞中基于糖酵解、线粒体和总 ATP 的产生，表明其除了破坏糖酵解外，还会破坏线粒体代谢[1]。
2DG-ODDA (400 μM；24 小时) 会诱导 4T1 三阴性乳腺癌细胞发生凋亡[1]。
2DG-ODDA (24 小时) 对 4T1 TNBC 细胞显示出细胞毒性，IC50 为 ~85 μM，比 2DG (IC50 = ~1.34 mM) 提高了 16 倍[1]。
2DG-ODDA (85 μM；24 h) 通过 CD36 (脂肪酸转运蛋白) 和葡萄糖转运蛋白被吸收，并被 α-Mannosidase 裂解，释放 2DG 以抑制 N- 糖基化并破坏细胞代谢[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2DG-ODDA 相关抗体:

Apoptosis Analysis[1]

Cell Line: 4T1 TNBC cells
Concentration: 400 μM
Incubation Time: 24 h
Result: Induced a marked increase in late-apoptotic populations.
体内研究
(In Vivo)

2DG-ODDA (7.5 mg/kg；皮下注射；每周 3 次，持续 2 周) 在 4T1 三阴性乳腺癌小鼠模型中抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice subcutaneously inoculated with 4T1 cells[1]
Dosage: 7.5 mg/kg
Administration: s.c.; three times weekly for 2 weeks
Result: Significantly attenuated tumor progression, with final mean tumor volumes ~40% lower than both control groups.
Showed no treatment-related weight loss or clinical signs of adverse events.
分子量

561.71

Formula

C28H51NO10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

2DG-ODDA 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2DG-ODDAApoptosisATP productionfatty acid transportcytotoxic effectsmetabolic vulnerabilitiesserum albuminglucose transportmitochondrial functiondual-transporter uptakeapoptosistumor growth suppressioncancer therapeuticglycolytic inhibitionmetabolic flux analysistriple-negative breast cancerα-mannosidasesInhibitorinhibitorinhibit

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