2. Others Apoptosis Epigenetics PI3K/Akt/mTOR
  3. Drug Derivative Apoptosis c-Myc AMPK mTOR
  4. 4-O-Methyl-ascochlorin

4-O-Methyl-ascochlorin (Compound MAC) 是 Ascochlorin (HY-101021) 的衍生物。4-O-Methyl-ascochlorin 能选择性诱导 K562 白血病细胞凋亡 (apoptosis)，G1 期阻滞，并下调 c-Myc 的表达。4-O-Methyl-ascochlorin可促进 AMPK 的磷酸化，抑制 mTOR 及其靶蛋白 (包括 p70S6 K 和 4E-BP-1) 的磷酸化。4-O-Methyl-ascochlorin 可用于白血病的研究。

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4-O-Methyl-ascochlorin

4-O-Methyl-ascochlorin Chemical Structure

CAS No. : 38561-40-9

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4-O-Methyl-ascochlorin 相关抗体

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin (HY-101021). 4-O-Methyl-ascochlorin can selectively induce apoptosis of K562 leukemia cells, cause G1 phase arrest and downregulate c-Myc expression. 4-O-Methyl-ascochlorin can promote the phosphorylation of AMPK and inhibit the phosphorylation of mTOR and its target proteins, including p70S6 K and 4E-BP-1. 4-O-Methyl-ascochlorin can be used for research of leukemia[1].

分子量

418.95

Formula

C24H31ClO4
CAS 号
结构分类
初始来源

Ascochyta viciae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-O-Methyl-ascochlorin 相关分类

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Keywords:

4-O-Methyl-ascochlorin38561-40-9Drug DerivativeApoptosisc-MycAMPKmTORDrug derivativeMycAMP-activated protein kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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